Ignite Creation Date:
2024-05-06 @ 2:49 PM
Last Modification Date:
2024-10-26 @ 1:37 PM
Study NCT ID:
NCT04434664
Status:
RECRUITING
Last Update Posted:
2024-07-09
First Post:
2020-06-10
Brief Title:
BLOCKade of Calcium Channels and Beta Adrenergic Receptors for the Treatment of Hypertension in HFpEF
Sponsor:
University of Pennsylvania
Organization:
University of Pennsylvania
Study Overview
Official Title:
BLOCKade of Calcium Channels and Beta Adrenergic Receptors for the Treatment of Hypertension in Heart Failure With Preserved Ejection Fraction BLOCK HFpEF Trial
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
BLOCK HFpEF
Brief Summary:
Heart failure with preserved ejection fraction HFpEF is a critical public health problem Heart failure HF affects over 5 million adults in the United States US and is a major source of morbidity mortality and impaired quality of life Approximately half of individuals with HF have a preserved left ventricular LV ejection fraction EF termed HF with preserved EF HFpEF While there are several effective pharmacologic therapies for HF with reduced ejection fraction HFrEF none have been identified for HFpEF Hypertension which is present in approximately 80 of individuals with HFpEF is the foremost modifiable risk factor for the development and progression of HFpEF Despite the clinical importance of hypertension in HFpEF there is limited information on how common antihypertensive agents particularly calcium channel blockers CCBs and β-blockers effect pathophysiologic mechanisms of HFpEF This is a mechanistic investigation of the role of dihydropyridine CCBs compared to β-blockers commonly used antihypertensive agents in clinical practice in targeting key physiologic abnormalities in HFpEF
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
True
Is an FDA AA801 Violation?:
None