Ignite Creation Date:
2024-05-05 @ 5:09 PM
Last Modification Date:
2024-10-26 @ 9:28 AM
Study NCT ID:
NCT00397436
Status:
COMPLETED
Last Update Posted:
2016-05-17
First Post:
2006-11-07
Brief Title:
Pilot Study of Protein Profiling of the Human Epidermal Cells After Ultraviolet Irradiation
Sponsor:
University of Minnesota
Organization:
University of Minnesota
Study Overview
Official Title:
Pilot Study of Protein Profiling of the Human Epidermal Cells After Ultraviolet Irradiation
Status:
COMPLETED
Status Verified Date:
2016-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The main focus of this pilot study is to construct a fairly complete protein profile of the epidermis This will allow us to study how the epidermis responds to external stressors such as ultra-violet We hypothesize that by using the cutting edge technology proteomics we will be able to construct a fairly complete profile of different epidermal cells keratinocytes epidermal nerve fibers ENFs melanocytes Langerhans celletc of normal and ultraviolet UV irradiated skin
Detailed Description:
We will investigate the changes of the epidermal cell proteome after UV irradiation to the forearms of healthy young male volunteers Knowledge of specific molecular markers may provide knowledge of basic biological systems and possibly targeted therapy of inflammation
By using combined proteomic methodologies we will be able to quantify protein changes at cytoplasmic and membrane protein levels of epidermal cells in normal vs irradiated skins
This study may allow us to obtain fairly comprehensive profile of membrane integrated and cytoplasmic proteins of epidermal cell populations which will facilitate our understand of biological responses to UV irradiation
By using combined proteomic methodologies we will be able to quantify protein changes at cytoplasmic and membrane protein levels of epidermal cells in normal vs irradiated skins
This study may allow us to obtain fairly comprehensive profile of membrane integrated and cytoplasmic proteins of epidermal cell populations which will facilitate our understand of biological responses to UV irradiation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None