Ignite Creation Date:
2024-05-05 @ 5:09 PM
Last Modification Date:
2024-10-26 @ 9:28 AM
Study NCT ID:
NCT00391833
Status:
COMPLETED
Last Update Posted:
2006-10-24
First Post:
2006-10-22
Brief Title:
Effect of Panax Ginseng on the Cognitive Performance in Alzheimers Disease
Sponsor:
Seoul National University Hospital
Organization:
Seoul National University Hospital
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2006-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
We investigate the clinical efficacy of Panax ginseng in Alzheimers disease AD
Detailed Description:
Alzheimers disease AD is characterized by a progressive decline of memory and intellectual abilities interfering activity in daily living the overall quality of life and ultimately leads to death Although pharmacologic treatments are currently approved for treating mild- to moderate AD using acetylcholinesterase inhibitors ACEI or memantine the NMDA antagonist for the advanced stage of AD the therapeutic efficacies need to be further improved
For millennia ginseng or its components have been used to treat medical conditions and the pharmacologic effects have been demonstrated in cardiovascular endocrine and immune system Attele et al 1999 In means of memory and learning a number of studies suggested that ginseng can attenuate learning deficits of damaged or ageing brains in rodent models Kennedy et al 2003 Zhao and McDaniel 1998 Nitta et al 1995 In studies with human healthy participants correspondently both acute and chronic dosage of ginseng increased the cognitive performance Kennedy et al 2001 Kennedy et al 2003 DAngelo et al 1986 Sorensen and Sonne 1996
In this study we we will investigate the contribution of ginseng treatment in increasing the cognitive improvement of AD patients In addition we will test various bio-markers and hematopoietic progenitor cell count in those included patients using their blood samples Patients with AD as well as memory decline will be included
For millennia ginseng or its components have been used to treat medical conditions and the pharmacologic effects have been demonstrated in cardiovascular endocrine and immune system Attele et al 1999 In means of memory and learning a number of studies suggested that ginseng can attenuate learning deficits of damaged or ageing brains in rodent models Kennedy et al 2003 Zhao and McDaniel 1998 Nitta et al 1995 In studies with human healthy participants correspondently both acute and chronic dosage of ginseng increased the cognitive performance Kennedy et al 2001 Kennedy et al 2003 DAngelo et al 1986 Sorensen and Sonne 1996
In this study we we will investigate the contribution of ginseng treatment in increasing the cognitive improvement of AD patients In addition we will test various bio-markers and hematopoietic progenitor cell count in those included patients using their blood samples Patients with AD as well as memory decline will be included
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None