Ignite Creation Date:
2024-05-05 @ 11:19 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005552
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
Isocyanate Dermal Exposures in Autobody Shops
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2004-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To characterize the skin route of exposure to the allergen hexamethylene diisocyanate HDI in the auto body industry
Detailed Description:
BACKGROUND
Isocyanates account for the highest number of reported cases of occupational asthma in the United States and developed countries Prevention however is limited by inadequate knowledge of isocyanate routes of exposure exposure patterns mechanisms of sensitization and other causal factors The Survey of Painters and Repairers of Auto Bodies by Yale SPRAY a five-year cross-sectional epidemiologic survey of painters and repairers of autobodies at Yale was therefore initiated to address these questions At the outset of Spray it was not known how frequent skin contact among the painters might be Moreover there is new and exciting data from animal studies demonstrating that dermal rather than respiratory contact may be crucial to immune sensitization leading to asthma Little is known so far about dermal exposure in autobody shops and its modifiers especially the effectiveness of personal protective equipment PPE in preventing workers from skin contamination by isocyanates
DESIGN NARRATIVE
The study was ancillary to the SPRAY study and was integrated into it The overall design was a cross-sectional investigation of 20 shops with 120 workers This would allow a better understanding of the complex basis for asthma risk in these workers and better recommendations to autobody shops and workers on protective measures for isocyanate dermal exposures
Specific aims included 1 Qualitatively and quantitatively assessing surface and skin contamination of HDI 2 Identifying modifiers that affected surface and skin contamination and specifically evaluating the effectiveness of personal protective equipment in protecting the skin from isocyanate contamination 3 Exploring the relationships of dermal exposure with airborne exposure biomarkers of systemic absorption and skin sensitization and asthma-developing risk
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Isocyanates account for the highest number of reported cases of occupational asthma in the United States and developed countries Prevention however is limited by inadequate knowledge of isocyanate routes of exposure exposure patterns mechanisms of sensitization and other causal factors The Survey of Painters and Repairers of Auto Bodies by Yale SPRAY a five-year cross-sectional epidemiologic survey of painters and repairers of autobodies at Yale was therefore initiated to address these questions At the outset of Spray it was not known how frequent skin contact among the painters might be Moreover there is new and exciting data from animal studies demonstrating that dermal rather than respiratory contact may be crucial to immune sensitization leading to asthma Little is known so far about dermal exposure in autobody shops and its modifiers especially the effectiveness of personal protective equipment PPE in preventing workers from skin contamination by isocyanates
DESIGN NARRATIVE
The study was ancillary to the SPRAY study and was integrated into it The overall design was a cross-sectional investigation of 20 shops with 120 workers This would allow a better understanding of the complex basis for asthma risk in these workers and better recommendations to autobody shops and workers on protective measures for isocyanate dermal exposures
Specific aims included 1 Qualitatively and quantitatively assessing surface and skin contamination of HDI 2 Identifying modifiers that affected surface and skin contamination and specifically evaluating the effectiveness of personal protective equipment in protecting the skin from isocyanate contamination 3 Exploring the relationships of dermal exposure with airborne exposure biomarkers of systemic absorption and skin sensitization and asthma-developing risk
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL062932 | NIH | None | httpsreporternihgovquickSearchR01HL062932 |