Ignite Creation Date:
2024-05-05 @ 5:09 PM
Last Modification Date:
2024-10-26 @ 9:28 AM
Study NCT ID:
NCT00393341
Status:
COMPLETED
Last Update Posted:
2015-08-31
First Post:
2006-10-25
Brief Title:
Quantitation of Endothelial Progenitor Cells as Markers of Tumor Angiogenesis in Breast Cancer
Sponsor:
Indiana University School of Medicine
Organization:
Indiana University
Study Overview
Official Title:
Quantitation of Endothelial Progenitor Cells as Markers of Tumor Angiogenesis in Breast Cancer
Status:
COMPLETED
Status Verified Date:
2015-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
EPC
Brief Summary:
We propose to quantitate endothelial progenitor cells EPCs in early and advanced breast cancer patients Peripheral blood will be drawn from the eligible patients Different type of EPCs will be isolated from the blood and quantitated
Detailed Description:
Accumulating evidence emphasizes the emerging role of circulating endothelial cells CECs and endothelial progenitor cells EPCs in tumor angiogenesis as surrogate markers and in the efficacy of anti-angiogenic therapies in breast cancer 22-27 Furstenberger et al 22 reported that CECs were significantly elevated in breast cancer patients and decreased during chemotherapy anthracycline andor taxane based However EPCs CD34VEGFR-2 as well as their progenitor cell population CD133CD34 and the population of CD34 stem cells increased together with VEGF erythropoietin and angiopoietin-2 levels Their data suggest that chemotherapy reduces mature CECs while mobilizing the EPC population Using real-time PCR and flow cytometry they also showed that CD146 an endothelial cell specific antigen was significantly increased in newly diagnosed breast cancer patients compared to healthy controls 23 Other studies also reported increased circulating EPCs in breast cancer patients in addition to CECs 2425 In another study circulating EPCs were not increased in cancer patients despite the high plasma VEGF levels 26 Another interesting aspect is that Mancuso et al 27 showed that CEC kinetics correlate with progression-free and overall survival but not circulating progenitor cells in metastatic breast cancer
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| IUCRO-0168 | None | None | None |