Ignite Creation Date:
2024-05-06 @ 2:47 PM
Last Modification Date:
2024-10-26 @ 1:37 PM
Study NCT ID:
NCT04425317
Status:
COMPLETED
Last Update Posted:
2022-02-17
First Post:
2020-05-27
Brief Title:
Detection of SARS-CoV-2 in Follicular Fluid and Cumulus-oocyte-complexes in COVID-19 Patients
Sponsor:
CRG UZ Brussel
Organization:
CRG UZ Brussel
Study Overview
Official Title:
Detection of SARS-CoV-2 in Follicular Fluid and Cumu-lus-oocyte-complexes From COVID-19 Patients During Controlled Ovarian Stimulation for ICSI Treatment
Status:
COMPLETED
Status Verified Date:
2022-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
COVID_OFF
Brief Summary:
Recently the world was shaken awake by a pandemic caused by a novel coronavirus SARS-CoV-2 Severe Acute Respiratory Syndrome Coronavirus 2 In most nations drastic isolation measures were taken to minimize the further spread of the Coronavirus Disease 2019 COVID-19 Being the first pandemic sparked by a Coronavirus little was known on COVID-19 and its implications on general health Our understanding on the virus and its potential effects on health is growing In Belgium the situation is stabilizing and doctors and healthcare workers are slowly recommencing routine work and consultations As also fertility treatments were abruptly interrupted many patients are in need to resume their treatment The limited evidence of SARS-CoV-2 on pregnancy seems to be rather satisfying1 but practically nothing is known about the possible impact of an active SARS-CoV-2 infection on female gametes Viral transmission occurs predominantly through respiratory droplets but transmission to gametes cannot be ruled out
Since the onset of the pandemic knowledge about the molecular details of SARS-CoV-2 infection rapidly grew Coronaviruses are enveloped RNA viruses For a virus to deliver their genome into the host cell attachment and entrance into that cell is a crucial step The coronavirus surface protein spike S mediates entry into target cells by binding to a cellular receptor and subsequent fusing of the viral envelope with a host cell membrane The SARS-CoV-2-S protein SARS-S utilizes angiotensin-converting enzyme 2 ACE2 as a receptor for host cell entry Host proteases such as transmembrane serine protease 2 TMPRSS2 are then needed to cleave the viral S protein allow-ing permanent fusion of the viral and host cell membranes2 Expression of ACE2 and TMPRSS2 has been shown in testicular uterine and placental cells Based on available transcriptomic data co-expression of ACE2 and TMPRSS2 is also seen on oocyte level but the possible impact on reproduction is unknown The BSG basigin or CD147 a receptor on host cells was also identified as a possible route for viral invasion
Since the onset of the pandemic knowledge about the molecular details of SARS-CoV-2 infection rapidly grew Coronaviruses are enveloped RNA viruses For a virus to deliver their genome into the host cell attachment and entrance into that cell is a crucial step The coronavirus surface protein spike S mediates entry into target cells by binding to a cellular receptor and subsequent fusing of the viral envelope with a host cell membrane The SARS-CoV-2-S protein SARS-S utilizes angiotensin-converting enzyme 2 ACE2 as a receptor for host cell entry Host proteases such as transmembrane serine protease 2 TMPRSS2 are then needed to cleave the viral S protein allow-ing permanent fusion of the viral and host cell membranes2 Expression of ACE2 and TMPRSS2 has been shown in testicular uterine and placental cells Based on available transcriptomic data co-expression of ACE2 and TMPRSS2 is also seen on oocyte level but the possible impact on reproduction is unknown The BSG basigin or CD147 a receptor on host cells was also identified as a possible route for viral invasion
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None