Ignite Creation Date:
2024-05-06 @ 2:47 PM
Last Modification Date:
2024-10-26 @ 1:37 PM
Study NCT ID:
NCT04427371
Status:
UNKNOWN
Last Update Posted:
2020-06-11
First Post:
2020-06-09
Brief Title:
The Effect and Mechanism of lncRNA NBR2 Regulating Endothelial Pyroptosis by Targeting GSDMD in Sepsis
Sponsor:
Jianfeng Xie
Organization:
Southeast University China
Study Overview
Official Title:
Zhongda Hospital School of Medicine Southeast University
Status:
UNKNOWN
Status Verified Date:
2020-06
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Sepsis is a life-threatening disease characterized by multi-organ failure due to dysregulated host response to infection with high global mortality of 30-50 One of the most important pathophysiologic hallmarks in sepsis is vascular endothelial injury that contributes to the severity and outcome of the syndrome Effective treatments for endothelial cell injury in sepsis have been lacking to improve prognosis Endothelial pyroptosis is a vital mechanism of vascular endothelial injury in sepsis mitigation or abolishment of endothelial cell pyroptosis alleviate vascular endothelial damage and improve the prognosis of sepsis mice Gasdermin D GSDMD mediated endothelial pyroptosis plays a critical role in modulating vascular endothelial injury in sepsis
Long non-coding RNA lncRNA as a class of non-coding protein RNA longer than 200 kD contributes to a variety of cell biological processes The dysregulation of lncRNA results in the occurrence and development of tumors diabetes sepsis and other diseases Therefore we detected lncRNA and mRNA expression profile in 26 blood samples of septic patients using Arraystar LncRNA Microarray We found lncRNA NBR2 regulates septic endothelial pyroptosis
To assess any correlation of pyroptosis levels with relevant endothelial cell injury parameters and determine the prognostic value in septic patients we measured the levels of pyroptosis in patients admitted to the Department of Critical Care Medicine for sepsis and investigated the correlation with related markers of endothelium injury Furthermore we determined the prognostic value of pyroptosis levels for the mortality of patients with sepsis
Long non-coding RNA lncRNA as a class of non-coding protein RNA longer than 200 kD contributes to a variety of cell biological processes The dysregulation of lncRNA results in the occurrence and development of tumors diabetes sepsis and other diseases Therefore we detected lncRNA and mRNA expression profile in 26 blood samples of septic patients using Arraystar LncRNA Microarray We found lncRNA NBR2 regulates septic endothelial pyroptosis
To assess any correlation of pyroptosis levels with relevant endothelial cell injury parameters and determine the prognostic value in septic patients we measured the levels of pyroptosis in patients admitted to the Department of Critical Care Medicine for sepsis and investigated the correlation with related markers of endothelium injury Furthermore we determined the prognostic value of pyroptosis levels for the mortality of patients with sepsis
Detailed Description:
We measured the levels of pyroptosis in patients admitted to the Department of Critical Care Medicine for sepsis and investigated the correlation with related markers of endothelium injury Furthermore we determined the prognostic value of pyroptosis levels for the mortality of patients with sepsis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None