Ignite Creation Date:
2024-05-05 @ 11:19 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00004343
Status:
UNKNOWN
Last Update Posted:
2005-06-24
First Post:
1999-10-18
Brief Title:
Study of Hypercortisolism in Cushings Syndrome and Stress-Induced Pseudo-Cushings Syndrome
Sponsor:
National Center for Research Resources NCRR
Organization:
National Center for Research Resources NCRR
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2003-12
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
OBJECTIVES
I Determine whether Cushings syndrome and stress-induced pseudo-Cushings syndrome can be differentiated by evaluating endogenous corticotropin-releasing hormone activity
I Determine whether Cushings syndrome and stress-induced pseudo-Cushings syndrome can be differentiated by evaluating endogenous corticotropin-releasing hormone activity
Detailed Description:
PROTOCOL OUTLINE Patients undergo a 30-hour infusion of deuterated cortisol with peripheral and petrosal vein measurements of adrenocorticotropin hormone ACTH and corticotropin-releasing hormone CRH Patients also have a 2-day low-dose dexamethasone suppression test
Patients with ACTH tumors are referred for pituitary surgery as indicated Patients without Cushings syndrome are entered as controls During scheduled radiologic procedures these subjects undergo ACTH and CRH sampling from the petrosal vein or cavernous sinus following a deuterated cortisol infusion
Patients with ACTH tumors are referred for pituitary surgery as indicated Patients without Cushings syndrome are entered as controls During scheduled radiologic procedures these subjects undergo ACTH and CRH sampling from the petrosal vein or cavernous sinus following a deuterated cortisol infusion
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| OHSU-3324 | None | None | None |