Ignite Creation Date:
2024-05-05 @ 5:08 PM
Last Modification Date:
2024-10-26 @ 9:28 AM
Study NCT ID:
NCT00399737
Status:
TERMINATED
Last Update Posted:
2006-11-15
First Post:
2006-11-14
Brief Title:
Effects of Peptides Derived From Fermented Milk on Blood Pressure Regulation System in Healthy Volunteers
Sponsor:
Assistance Publique - Hôpitaux de Paris
Organization:
Assistance Publique - Hôpitaux de Paris
Study Overview
Official Title:
None
Status:
TERMINATED
Status Verified Date:
2006-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Several milk proteins are precursors of peptides released during fermentation which possess various biochemical and physiological properties Among them some peptides have been reported to inhibit angiotensin-converting enzyme ACE in vitro an enzyme implicated in blood pressure regulation and to lower blood pressure BP in hypertensive rats and in a small sample of patients with hypertension One possible mechanism for the BP lowering effect is inhibition of ACE Prior investigating BP lowering effect of these peptides in a large cohort of hypertensive patients it is necessary to assess in depth their potency to inhibit ACE in vivo in humans and to compare it to that induced by a well-known ACE inhibitor
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None