Ignite Creation Date:
2024-05-06 @ 2:45 PM
Last Modification Date:
2024-10-26 @ 1:36 PM
Study NCT ID:
NCT04415502
Status:
UNKNOWN
Last Update Posted:
2020-06-04
First Post:
2020-05-31
Brief Title:
CTHRC1 A Biomarker for Evaluation of Rheumatoid Arthritis Disease Activity
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
CTHRC1 A Biomarker for Evaluation of Rheumatoid Arthritis Disease Activity
Status:
UNKNOWN
Status Verified Date:
2020-06
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of the study is to determine whether plasma levels of the collagen triple helix repeat containing CTHRC1 protein can serve as a blood-based biomarker for diagnosis of rheumatoid arthritis RA and furthermore its correlation with disease activity
Detailed Description:
Rheumatoid arthritis RA is a chronic progressive autoimmune disease of synovial joints Characterized by periods of flares with high disease activity involving both a systemic immune response and tissue-specific inflammatory events that can lead to erosive joint and bone destruction and subsequent disability Currently diagnosis of RA is based mainly on the extent of tenderness and swelling of the joints levels of acute-phase reactants such as C-reactive protein CRP erythrocyte sedimentation rateESR high titers of rheumatoid factor RF and high titers of antibodies against cyclic citrullinated peptide anti-CCP in the plasma Recently reported increased levels of collagen triple helix repeat containing 1 protein CTHRC1 are strongly associated with the severity of murine proteoglycan-induced arthritis and collagen antibody-induced murine arthritis CAIA further CTHRC1 expression in murine experimental arthritis is increased in the synovium and specifically detected in activated murine located at the synovial intimal lining and at the bone-pannus interface Of interestThe expression pattern of CTHRC1 in pannus its role in the function of FLS relevant to cartilage damage in RA and CTHRC1s association with disease severity in murine arthritis raised the question of whether CTHRC1 could be used as a marker for RA diagnosis and monitoring of disease activity in patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None