Ignite Creation Date:
2024-05-05 @ 5:08 PM
Last Modification Date:
2024-10-26 @ 9:28 AM
Study NCT ID:
NCT00396396
Status:
UNKNOWN
Last Update Posted:
2006-11-06
First Post:
2006-11-03
Brief Title:
Role of Acetylcysteine in Creatinine Clearance
Sponsor:
Eastern Virginia Medical School
Organization:
Eastern Virginia Medical School
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2006-11
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to investigate the exact role of Acetylcysteine Mucomyst in altering creatinine clearance Prior studies have shown the protective effects of Acetylcysteine on contrast-induced renal dysfunction In these studies Acetylcysteine lowered the incidence of serum creatinine elevation after administration of radiographic contrast agents Not only was the increase in serum creatinine prevented the studies also demonstrated a significant increase in creatinine clearance after administration of the agent These prior studies did not evaluate if the increase in creatinine clearance was indeed from a protective benefit of Acetylcysteine in preserving the GFR versus simply increasing the proximal tubular creatinine secretion without actually affecting the GFR We propose an experiment to help support our hypothesis that Acetylcysteine increases creatinine clearance via an increase in proximal tubular secretion of creatinine
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None