Ignite Creation Date:
2024-05-06 @ 2:43 PM
Last Modification Date:
2024-10-26 @ 1:36 PM
Study NCT ID:
NCT04406922
Status:
COMPLETED
Last Update Posted:
2021-04-19
First Post:
2020-01-21
Brief Title:
Circadian Rhythmicity in Cold-induced Thermogenesis
Sponsor:
Leiden University Medical Center
Organization:
Leiden University Medical Center
Study Overview
Official Title:
The Impact of Circadian Rhythmicity in Cold-induced Thermogenesis in Lean and Obese Subjects
Status:
COMPLETED
Status Verified Date:
2021-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
COLDR
Brief Summary:
This study aims to investigate whether maximum cold-induced non-shivering thermogenesis eg thermogenesis as a consequence of BAT activity differs between morning and evening
Detailed Description:
Brown adipose tissue BAT recently emerged as a novel player in energy expenditure EE in humans as it combusts fatty acids and glucose towards heat Human BAT can be activated by sympathetic stimulation resulting from cold exposure or treatment with sympathomimetic drugs Short-term acclimation to mild cold was shown to reduce fat mass in obese subjects and decrease peripheral insulin resistance of patients with T2DM Recently in preclinical studies the investigators showed that BAT has a circadian rhythm It is currently unknown whether this is also the case in humans The investigators postulate that BAT activity should display a circadian rhythm that adapts to changes in circadian behavior and may determine glucoselipid levels throughout the day
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None