Ignite Creation Date:
2024-05-05 @ 5:07 PM
Last Modification Date:
2024-10-26 @ 9:28 AM
Study NCT ID:
NCT00393666
Status:
COMPLETED
Last Update Posted:
2016-01-26
First Post:
2006-10-23
Brief Title:
Why Are Patients With Absence Seizures Absent A Brain Imaging Study
Sponsor:
Yale University
Organization:
Yale University
Study Overview
Official Title:
Functional Neuroimaging in Childhood Absence Epilepsy
Status:
COMPLETED
Status Verified Date:
2016-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Our study examines which different brain regions are involved in child absence seizures and how they are related to attention and cognition
Detailed Description:
The fundamental mechanisms of altered brain function and impaired attention in childhood absence epilepsy CAE are not known Absence seizures consist of brief 5-10 seconds episodes of unresponsiveness associated with a 3-4 Hz spike-wave discharge on electroencephalogram EEG CAE affects 10-15 of children with epilepsy In addition to the deficit during seizures many children also suffer from milder attention impairment between absence episodes which may not be due entirely to medications Impaired attention during and between absence seizures has a major negative impact on patient quality of life due to deficits in school performance potential for injuries and social stigma
Recent studies suggest that impaired cognition in so-called generalized absence seizures may in fact depend on dysfunction in specific brain networks Our central hypothesis is abnormal function in focal brain regions such as the anterior cingulatemedial prefrontal cortex and medial thalamus causes impaired attention both during and between seizures in CAE If confirmed this may lead to innovative regional therapies targeted at improving impaired attention in CAE Specifically we hope to determine which specific cortical and sub-cortical networks are selectively involved when patients show impaired attention Using simultaneous EEG and functional magnetic resonance imaging fMRI we will determine which brain regions are involved in absence seizures while using a continuous performance task CPT to test attention vigilance in the same patients A few neuropsychology tests will then follow Patients will be reimbursed 100 as well as all travel and parking expenses
For more information please visit wwwyalecaecom
Recent studies suggest that impaired cognition in so-called generalized absence seizures may in fact depend on dysfunction in specific brain networks Our central hypothesis is abnormal function in focal brain regions such as the anterior cingulatemedial prefrontal cortex and medial thalamus causes impaired attention both during and between seizures in CAE If confirmed this may lead to innovative regional therapies targeted at improving impaired attention in CAE Specifically we hope to determine which specific cortical and sub-cortical networks are selectively involved when patients show impaired attention Using simultaneous EEG and functional magnetic resonance imaging fMRI we will determine which brain regions are involved in absence seizures while using a continuous performance task CPT to test attention vigilance in the same patients A few neuropsychology tests will then follow Patients will be reimbursed 100 as well as all travel and parking expenses
For more information please visit wwwyalecaecom
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| HIC 18514 | None | None | None |