Ignite Creation Date:
2024-05-05 @ 11:19 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001546
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Circadian Regulation of Sleep in Habitual Short Sleepers and Long Sleepers
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Circadian Regulation of Sleep in Habitual Short Sleepers and Long Sleepers
Status:
COMPLETED
Status Verified Date:
1999-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Routine sleep duration varies greatly among individuals The biological meaning of this variation is unknown
The term circadian rhythm refers to the biological clock that regulates the timing of falling asleep waking up and secretion of hormones like melatonin Melatonin is secreted at night Previous studies have shown that melatonin may play a role in the regulation of sleep
The purpose of this study is to learn whether the duration of nighttime nocturnal melatonin secretion is longer in people with long regular sleep duration than people with short sleep duration
Researchers will compare levels of melatonin and cortisol body temperature sleepiness and sleep in two extreme groups Group one will be made up of people with short sleep duration lasting less than 6 hours Group two will be made up of people with long sleep duration lasting more than 9 hours
The term circadian rhythm refers to the biological clock that regulates the timing of falling asleep waking up and secretion of hormones like melatonin Melatonin is secreted at night Previous studies have shown that melatonin may play a role in the regulation of sleep
The purpose of this study is to learn whether the duration of nighttime nocturnal melatonin secretion is longer in people with long regular sleep duration than people with short sleep duration
Researchers will compare levels of melatonin and cortisol body temperature sleepiness and sleep in two extreme groups Group one will be made up of people with short sleep duration lasting less than 6 hours Group two will be made up of people with long sleep duration lasting more than 9 hours
Detailed Description:
Habitual sleep duration varies greatly among individuals The biological meaning of this variation is unknown The present project proposes that differences in habitual sleep duration are associated with differences in the output of the endogenous circadian pacemaker which programs the internal biological night The protocol hypothesizes that the duration of the internal biological night as defined by the nocturnal intervals of detectable plasma melatonin levels low body temperature low EEG activity in the high-frequency alpha band increasing sleepiness and increasing plasma cortisol levels is longer in habitual long sleepers sleep duration greater than 9 hours than in short sleepers less than 6 hours Since recent results in healthy subjects suggest that melatonin has some soporific or hypnotic properties we furthermore hypothesize that the level of nocturnal melatonin secretion is higher in long sleepers than in short sleepers The circadian rhythms of plasma melatonin body temperature waking EEG activity subjective sleepiness and plasma cortisol will be assessed in a 40-hour constant routine protocol In addition a 36-hour extended bed rest protocol will be carried out in order to study spontaneous sleep duration and sleep structure under ad lib conditions while time cues and social cues are absent It is hypothesized that as a consequence of differences in the circadian output long sleepers will sleep more have a different sleep structure and spontaneously wake up on a lower level of homeostatic sleep pressure than short sleepers Finally we intend to determine whether differences in habitual sleep duration between long and short sleepers are associated with dysthymic and hypomanic characteristics of mood respectively We are asking to study a total of 15 long sleepers and 15 short sleepers Given that we have already studied 9 long sleepers and 9 short sleepers we anticipate that 72 patient-days per year for one year would be required to complete the study
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 96-M-0087 | None | None | None |