Ignite Creation Date:
2024-05-06 @ 2:35 PM
Last Modification Date:
2024-10-26 @ 1:33 PM
Study NCT ID:
NCT04360252
Status:
RECRUITING
Last Update Posted:
2024-03-18
First Post:
2020-04-20
Brief Title:
Gracie Diet for Gastroesophageal Reflux Disease
Sponsor:
Johns Hopkins University
Organization:
Johns Hopkins University
Study Overview
Official Title:
Gracie Diet for Gastroesophageal Reflux Disease
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
GERD is a common and chronic world-wide disease Cardinal symptoms of this condition are heartburn-regurgitation and sometimes with extra-intestinal symptoms that can affect patients quality of life Proton pump inhibitors PPIs potently inhibit gastric acid secretion and are widely used for treatment of acid-related diseases This class of medications is the most widely used for the management of GERD H2 Receptor Antagonists H2RAs are another type of medication used to of uncomplicated GERD gastric or duodenal ulcers gastric hypersecretion and for mild to infrequent heartburn or indigestion H2RAs decrease gastric acid secretion by reversibly binding to histamine H2 receptors located on gastric parietal cells thereby inhibiting the binding and action of the endogenous ligand histamine
Dietary modification is endorsed by the National Institutes of Health and the American College of Gastroenterology as a first-line therapy for patients with GERD The Gracie Diet is thought to play an important role in the prevention of GERD The concept behind this diet is that the consumption of proper food combinations promotes optimal health by preventing unhealthy chemical reactions in the digestive process such as fermentation and acidity
This diet describes the benefits of combining different foods together and the downsides of combining others It provides guidance on avoiding specific foods and combinations of foods that may aggravate GERD and adopting meal spacing habits to improve overall health outcomes The idea is that such dietary changes support more efficient digestion and encourage healthier lifestyles ie smoking cessation elimination of alcohol intake avoidance of soda consumption and desserts This diet also supports the acquisition of healthy eating habits characterized by higher consumption of fruits vegetables and whole grains and encourages a reduction in the intake of saturated fat sodium added sugars and canned foods Limiting beverage consumption of water or fresh coconut water between meals is also encouraged In this pilot study the investigators hypothesized that the Gracie diet it could be an alternative option to improve GERD symptoms in those patients who do not respond to standard doses of PPI andor H2 receptor antagonists
Dietary modification is endorsed by the National Institutes of Health and the American College of Gastroenterology as a first-line therapy for patients with GERD The Gracie Diet is thought to play an important role in the prevention of GERD The concept behind this diet is that the consumption of proper food combinations promotes optimal health by preventing unhealthy chemical reactions in the digestive process such as fermentation and acidity
This diet describes the benefits of combining different foods together and the downsides of combining others It provides guidance on avoiding specific foods and combinations of foods that may aggravate GERD and adopting meal spacing habits to improve overall health outcomes The idea is that such dietary changes support more efficient digestion and encourage healthier lifestyles ie smoking cessation elimination of alcohol intake avoidance of soda consumption and desserts This diet also supports the acquisition of healthy eating habits characterized by higher consumption of fruits vegetables and whole grains and encourages a reduction in the intake of saturated fat sodium added sugars and canned foods Limiting beverage consumption of water or fresh coconut water between meals is also encouraged In this pilot study the investigators hypothesized that the Gracie diet it could be an alternative option to improve GERD symptoms in those patients who do not respond to standard doses of PPI andor H2 receptor antagonists
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None