Ignite Creation Date:
2024-05-05 @ 5:07 PM
Last Modification Date:
2024-10-26 @ 9:28 AM
Study NCT ID:
NCT00393692
Status:
COMPLETED
Last Update Posted:
2018-10-11
First Post:
2006-10-26
Brief Title:
Fundus Autofluorescence Imaging in Age-related Macular Degeneration Using Confocal Scanning Laser Ophthalmoscopy
Sponsor:
University Hospital Bonn
Organization:
University Hospital Bonn
Study Overview
Official Title:
Prospective Natural History Study of Fundus Autofluorescence Imaging in Age-related Macular Degeneration FAM-Study Using Confocal Scanning Laser Ophthalmoscopy
Status:
COMPLETED
Status Verified Date:
2018-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to define phenotypic variations in atrophic Age-Related Macular Degeneration AMD and to identify predictive factors for disease progression based on fundus autofluorescence imaging
Detailed Description:
Age-related macular degeneration AMD is the leading cause of legal blindness in the industrialized world beyond 50 years of age Ageing changes of the retinal pigment epithelium RPE play a key role in the pathogenesis of the disease In postmitotic RPE cells autofluorescent lipofuscin granules accumulate with age in the lysosomal compartment mainly as a byproduct of constant phagocytosis of membranous disks shed from photoreceptor outer segments With the advent of confocal scanning laser ophthalmoscopy fundus autofluorescence mediated by RPE-lipofuscin accumulation can be visualized in vivo We plan to identify fundus autofluorescence changes as predictive factors for the development of late stage manifestations and their variation over time Furthermore we plan to determine the effect of increased focal accumulations of autofluorescent material on retinal sensitivity using fundus perimetry Examination of human donor eyes with AMD will allow for correlation of fundus autofluorescence alterations in vivo and in vitro These investigations will be performed not only to better understand the role of lipofuscin accumulation in AMD but also to manipulate these mechanisms for both experimental and therapeutic ends
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| Ma 17231-1 | None | None | None |
| SPP 1088 | None | None | None |
| Ho 19261-3 | None | None | None |
| DFG Priority Program AMD | None | None | None |
| Ho 19263-1 | None | None | None |