Ignite Creation Date:
2024-05-06 @ 2:35 PM
Last Modification Date:
2024-10-26 @ 1:33 PM
Study NCT ID:
NCT04363554
Status:
COMPLETED
Last Update Posted:
2020-04-30
First Post:
2020-04-23
Brief Title:
The Kidneys Ability to Concentrate and Dilute Urine in Patients With Autosomal Dominant Polycystic Kidney Disease
Sponsor:
Regional Hospital Holstebro
Organization:
Regional Hospital Holstebro
Study Overview
Official Title:
The Kidneys Ability to Concentrate and Dilute Urine in Patients With Autosomal Dominant Polycystic Kidney Disease ADPKD or Other Cause of Chronic Renal Disease Compared to Healthy Volunteers
Status:
COMPLETED
Status Verified Date:
2020-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
POVA
Brief Summary:
The ability to concentrate and dilute urine is primarily regulated via vasopressin AVP dependent Aquaporin-2 water channels AQP2 channels in the kidneys collecting duct Autosomal dominant polycystic kidney disease ADPKD is a common genetic disorder characterized by the formation of cyst in the kidneys causing gradual renal function-loss Previous studies indicate that ADPKD patients have decreased urine concentration higher plasma osmolality and plasma AVP levels compared to healthy controls Previous studies also indicate that ADPKD patients dysregulated AVP is an important factor for the pathogenesis and progression of the disease It is unclear whether ADPKD patients ability to concentrate and dilute urine are different from those of other cause of chronic renal disease to the same degree It is also unclear what mechanisms cause the decreased ability to concentrate and dilute urine in chronic renal disease patients The purpose of this trial is to investigate the difference in renal function during concentration and dilution test in a case-control randomized cross-examination study with ADKPD patients or other cause of chronic renal disease compared to healthy volunteers
Detailed Description:
The aim is to measure the difference in renal function including kidney tubular function blood pressure and vasoactive hormones in patients with Autosomal dominant polycystic kidney disease ADPKD or other chronic renal disease compared to healthy volunteers during concentration and dilution test
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None