Ignite Creation Date:
2024-05-06 @ 2:34 PM
Last Modification Date:
2024-10-26 @ 1:33 PM
Study NCT ID:
NCT04351451
Status:
COMPLETED
Last Update Posted:
2020-04-17
First Post:
2020-04-12
Brief Title:
Hypomagnesemia and Hypocalcemia Association Following Thyroidectomy
Sponsor:
King Saud University
Organization:
King Saud University
Study Overview
Official Title:
Hypomagnesemia and Hypocalcemia Association Following Thyroidectomy
Status:
COMPLETED
Status Verified Date:
2020-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Magnesium plays a role in the active transport of calcium Ca2 and potassium ions across cell membranes Most of it is intracellular or in the bone however less than 1 of magnesium is in the blood serum Hypoparathyroidism post thyroidectomy leads to acute Hypocalcemia that leads to hypomagnesemia The relation of Ca2 and magnesium Mg2 metabolism is complex and mainly related to the interaction of these cations with parathyroid post thyroidectomy Mg2 is an essential regulator of Ca2 flux and intracellular action of Ca2 Hypomagnesaemia impairs hypocalcaemia induced PTH release which is corrected rapidly after magnesium replacement Attempting to correct only hypocalcemia may prolong symptoms It is important to monitor both Ca2 Mg2 levels following thyroidectomy to facilitate prompt resolution of symptoms
Aim of the study is to highlight the prevalence of hypomagnesemia following thyroidectomy and its association with hypocalcemia which mandate early recognition and treatment to prevent prolongation of hypocalcemia and permanent hypoparathyroidism
Methods
IRB obtained E20-4615 informed consent taken from all patient This is prospective open Label observational study in patients underwent thyroidectomy the study period was from January 2019 to January 2020 Total of 74 patients with normal renal function Corrected serum Ca2 magnesium phosphate level and vitamin D level are all checked pre operatively and in the first post-operative day
Result
Post thyroidectomy 568 of patients had hypomagnesemia 5951 patients had hypocalcemia and 419 of patients had low both Ca2 and Mg2 P0004
Conclusion
Hypocalcemia and hypomagnesemia following thyroidectomy is of multi factorial related mainly to Ca2 Mg2 interaction
Keywords Hypomagnesemia Hypocalcemia Thyroidectomy
Aim of the study is to highlight the prevalence of hypomagnesemia following thyroidectomy and its association with hypocalcemia which mandate early recognition and treatment to prevent prolongation of hypocalcemia and permanent hypoparathyroidism
Methods
IRB obtained E20-4615 informed consent taken from all patient This is prospective open Label observational study in patients underwent thyroidectomy the study period was from January 2019 to January 2020 Total of 74 patients with normal renal function Corrected serum Ca2 magnesium phosphate level and vitamin D level are all checked pre operatively and in the first post-operative day
Result
Post thyroidectomy 568 of patients had hypomagnesemia 5951 patients had hypocalcemia and 419 of patients had low both Ca2 and Mg2 P0004
Conclusion
Hypocalcemia and hypomagnesemia following thyroidectomy is of multi factorial related mainly to Ca2 Mg2 interaction
Keywords Hypomagnesemia Hypocalcemia Thyroidectomy
Detailed Description:
Methods
A prospective study for 1 year starting 112019 to 112020 A total 74 patients with normal renal function admitted for thyroidectomy Preoperative serum calcium magnesium phosphate and vitamin D level all checked Postoperatively corrected serum calcium magnesium and phosphate level are checked The serum calcium less than 212mmoll is corrected with oral or IV calcium infusion plus vitamin D depending on the severity of symptoms Any serum magnesium less than 075mmoll is corrected with infusion magnesium sulfate Calcium and magnesium level monitored and corrected according to the result
Statistical analysis
Statistical analysis was performed using statistical package for the social sciences SPSS version 230 software SPSS Inc Chicago ILUSA If normal distributed continuous variable were presented as mean SD Student t-test for paired observation was used for statistical Pearson Chi-square test was used to compare the percentage for categorical variables P less than 005 indicate statistically significant difference
A prospective study for 1 year starting 112019 to 112020 A total 74 patients with normal renal function admitted for thyroidectomy Preoperative serum calcium magnesium phosphate and vitamin D level all checked Postoperatively corrected serum calcium magnesium and phosphate level are checked The serum calcium less than 212mmoll is corrected with oral or IV calcium infusion plus vitamin D depending on the severity of symptoms Any serum magnesium less than 075mmoll is corrected with infusion magnesium sulfate Calcium and magnesium level monitored and corrected according to the result
Statistical analysis
Statistical analysis was performed using statistical package for the social sciences SPSS version 230 software SPSS Inc Chicago ILUSA If normal distributed continuous variable were presented as mean SD Student t-test for paired observation was used for statistical Pearson Chi-square test was used to compare the percentage for categorical variables P less than 005 indicate statistically significant difference
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None