Viewing Study NCT04356053



Ignite Creation Date: 2024-05-06 @ 2:33 PM
Last Modification Date: 2024-10-26 @ 1:33 PM
Study NCT ID: NCT04356053
Status: UNKNOWN
Last Update Posted: 2021-10-12
First Post: 2020-04-17

Brief Title: Systematic Screening for Primary Immunodeficiencies in Patients Hospitalized for Severe Infections in Intensive Care
Sponsor: University Hospital Montpellier
Organization: University Hospital Montpellier

Study Overview

Official Title: Systematic Screening for Primary Immunodeficiencies in Patients Hospitalized for Severe Infections in Intensive Care DIPREA
Status: UNKNOWN
Status Verified Date: 2021-10
Last Known Status: RECRUITING
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: DIPREA
Brief Summary: Currently about 90 cases of infection in children are reported every year in pediatric intensive care a disease considered to be the main cause of hospitalization of children 16 of invasive pneumococcal infections are linked to a genetic abnormality in immunity Herpetic encephalitis has become a model of genetic infectious disease with new mutations identified in the TLR3 pathway Severe infections are no longer the result of chance and can be the way to reveal a primary immune deficiency In this context the investigators propose to evaluate the incidence of hereditary immune deficiency after a systematic immunological screening in children admitted for a severe infection in pediatric intensive care unit ICU
Detailed Description: Severe infection requiring admission in intensive care unit ICU are not so rare A retrospective pilot study conducted at Montpellier University Hospital Center UHC between 2013 and 2015 showed that 197 of the pediatric ICU admissions were related to a severe infection An isolated severe infectious episode could be related to a hereditary immune deficiency HID even though there are no history of recurrent clinical signs and biological stigmata For example Gaschignard and colleagues considered that 16 of the invasive pneumococcal infections are related to a genetic defect of immunity doi 101093cidciu274 Growing evidence has shown that severe infectious diseases occurring in childhood are attributed to inborn errors of immunity doi 101073pnas1521651112 While the nosology of severe infections has strong links to inherited immune deficiency that are rare diseases affecting less than 1 birth 5000 there are no prospective studies that assessed the incidence of primary immune deficiencies in children who presented a severe infection

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: False
Is a FDA Regulated Device?: False
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None