Ignite Creation Date:
2024-05-06 @ 2:32 PM
Last Modification Date:
2024-10-26 @ 1:32 PM
Study NCT ID:
NCT04345198
Status:
COMPLETED
Last Update Posted:
2020-04-14
First Post:
2020-04-05
Brief Title:
Adrenal Artery Ablation for Primary Aldosteronism With Resistant Hypertension
Sponsor:
Third Military Medical University
Organization:
Third Military Medical University
Study Overview
Official Title:
Adrenal Artery Ablation Treats Primary Aldosteronism With Resistant Hypertension AAA-RHT
Status:
COMPLETED
Status Verified Date:
2020-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Primary aldosteronismPA is the most common endocrine cause of resistant hypertension Surgery and medicine are the main treatment for PA by the current guidelines Howeveronly a small part of patients with PA meet the surgical criteria and most of them have to take spironolactone or other antihypertensive drugs for long time On the other side long-term inhibition of aldosterone receptor may cause hyperkalemia male breast hyperplasia and other adverse reactions Moreover hyperaldosterone is still not corrected by spironolactone which cause extensive cerebrovascular damages even though blood pressure and blood potassium had been normalized
With the development of adrenal vein sampling and adrenal ablation the precise diagnosis and treatment of PA is possible Selective adrenal artery ablation AAA was observed with significant decrease of blood aldosterone and blood pressure in patients with PA which made it promissing that primary aldosteronism with resistant hypertension could be relieved by adrenal artery ablation
With the development of adrenal vein sampling and adrenal ablation the precise diagnosis and treatment of PA is possible Selective adrenal artery ablation AAA was observed with significant decrease of blood aldosterone and blood pressure in patients with PA which made it promissing that primary aldosteronism with resistant hypertension could be relieved by adrenal artery ablation
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None