Ignite Creation Date:
2024-05-05 @ 11:19 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00008788
Status:
UNKNOWN
Last Update Posted:
2005-06-24
First Post:
2001-01-16
Brief Title:
Osteoporosis in Children and Adults Following Liver Transplantation
Sponsor:
National Center for Research Resources NCRR
Organization:
National Center for Research Resources NCRR
Study Overview
Official Title:
Osteoporosis in Children and Adults Following Liver Transplantation
Status:
UNKNOWN
Status Verified Date:
2003-12
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This pilot project aims to 1 estimate the prevalence of osteoporosis in adults having undergone liver transplantation in childhood and 2 identify risk factors for osteoporosis in this group We aim to study 40 individuals
Detailed Description:
Background Osteoporosis is defined as an absolute decrease in the amount of bone volume andor density Chronic liver disease is associated with osteoporosis in both adults and children Bone density is also decreased in the months immediately after liver transplantation but improves to pretransplant values after 1 to 2 years Immunosuppressive agents most notably steroids are a cause of osteoporosis However studies on adults have shown that bone densities afer transplantation continue to improve within the normal range for healthy adults In the case of children bone accretion is necessary for growth Chronic liver disease and transplantation in childhood will have an adverse effect on bone metabolism and the outcome in terms of bone density after the growth period cannot be predicted on individuals transplanted as adults or other transplant groups
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?: