Ignite Creation Date:
2024-05-05 @ 5:06 PM
Last Modification Date:
2024-10-26 @ 9:28 AM
Study NCT ID:
NCT00383825
Status:
COMPLETED
Last Update Posted:
2006-10-04
First Post:
2006-10-02
Brief Title:
ICG Angiography in Amniotic Membrane Graft and Conjunctival Autograft After Pterygium Excision
Sponsor:
Baskent University
Organization:
Baskent University
Study Overview
Official Title:
Interventional Study of Vascularization Detected by ICG Angiography in Amniotic Membrane Graft and Conjunctival Autograft After Pterygium Excision
Status:
COMPLETED
Status Verified Date:
2006-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To evaluate graft vascularization and compare the vascularization patterns of conjunctival autografts with amniotic membrane grafts to better understand the factors involved in pterygium recurrence
Detailed Description:
The vascularization and perfusion of conjunctival autografts and amniotic membrane grafts after surgery may have significance in terms of pterygium recurrence and progression Fluorescein angiography of the anterior ocular segment has been used to evaluate ocular inflammation in scleral inflammation However when fluorescein is used the quality of the angiograms is limited by rapid extravasation of the dye due to diffusion through the fenestrated capillaries of the conjunctiva and episclera Because fluorescein has a low molecular weight and is not a protein bound molecule patchy leakage during the first transit of the dye which obscures the angiographic details even before the late phases of the angiogram can be seen
In contrast indocyanine green ICG is a larger molecule than fluorescein and is more highly found in protein bound form Therefore it remains within the fenestrated vessels and shows negligible extravasation which makes it ideal for use in anterior segment angiography
Tan and coworkers have shown that the morphology of pterygium recurrence inevitably reflects a high degree of vascularity
In this prospective study we evaluated the anterior segment indocyanine green angiography ICGA findings for graft vascularization after primary pterygium excision with LCAT or AMT
In contrast indocyanine green ICG is a larger molecule than fluorescein and is more highly found in protein bound form Therefore it remains within the fenestrated vessels and shows negligible extravasation which makes it ideal for use in anterior segment angiography
Tan and coworkers have shown that the morphology of pterygium recurrence inevitably reflects a high degree of vascularity
In this prospective study we evaluated the anterior segment indocyanine green angiography ICGA findings for graft vascularization after primary pterygium excision with LCAT or AMT
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None