Viewing Study NCT04344470



Ignite Creation Date: 2024-05-06 @ 2:31 PM
Last Modification Date: 2024-10-26 @ 1:32 PM
Study NCT ID: NCT04344470
Status: COMPLETED
Last Update Posted: 2024-04-05
First Post: 2020-04-11

Brief Title: Study of Volition Behavioral Analysis and Clinical Neurophysiological Analysis
Sponsor: National Institute of Neurological Disorders and Stroke NINDS
Organization: National Institutes of Health Clinical Center CC

Study Overview

Official Title: Study of Volition Behavioral Analysis and Clinical Neurophysiological Analysis
Status: COMPLETED
Status Verified Date: 2024-03-21
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: None
Brief Summary: Background

Free will can be defined as the belief that people have control over their thoughts and movements The topic of free will is controversial and is still being debated Science has only partial answers to questions about free will so researchers want to learn more about it They want to assess the role of consciousness when intentions are present with behavior This could help to explain the causal role of consciousness in movement or decisions

Objective

To learn more about free will

Eligibility

Healthy right-handed adults ages 25-45

Design

Participants will be screened with medical history physical exam and neurological exam

Participants will have 1 study visit It will last up to 4 hours

Participants will sit in a comfortable chair in front of a screen They will perform some or all of the following tasks

Visual Task Participants will watch different stimuli on the screen and answer simple questions

Electroencephalography EEG An EEG records the electrical activity of the brain brain waves For the EEG small electrodes are put on the scalp with an electrode cap A gel is placed in the space between the electrodes and the scalp Participants brain waves will be recorded including while they decide whether to move their thumb

ChoiceReaction Time Task Participants will watch different stimuli on the screen and react to them by moving their wrist During this task they will wear an EEG cap on their head and electrodes on their arms and wrists

Electromyography Small electrodes will be attached to participants skin Their muscle activity will be recorded while they decide whether to move their wrist and during the movement itself

Transcranial Magnetic Stimulation TMS TMS is a non-invasive brain stimulation that uses magnetic field to stimulate nerve cells in your brain TMS can increase or decrease brain activity in particular area of your brain TMS operates completely outside of the body and is generally very well tolerated
Detailed Description: Study Description

The main focus of this protocol will be to try to identify the quale of free will its electrophysiological correlates and to determine whether this quale plays a causative role in movement

Objectives

Primary Objectives

We will be doing a series of experiments In the first experiments we want to explore the behavioral response of normal subjects when they move after a visual stimulus that can be seen or unseen We want to study behavior in different conditions with movement triggered by stimuli that are seen and not seen Furthermore we want to analyze the EEG related to those stimuli to explore sensory and motor processing

Endpoints

Primary Endpoints

Reaction time and accuracies of the responses to different stimuli in different conditions will be identified as well as the subjects subjective experiences EEG ERP shapes and microstates patterns will also be investigated

Study Population

Up to 50 healthy volunteers of both genders between the ages of 25-45 fluent in English and right-handed

Participant Duration

The total study is expected to last 48 months with each individual expected to participate in a single 4-hour outpatient visit at the NIH Clinical Center but there can be multiple visits

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: False
Is a FDA Regulated Device?: False
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None
Secondary IDs
Secondary ID Type Domain Link
20-N-0077 None None None