Ignite Creation Date:
2024-05-06 @ 2:30 PM
Last Modification Date:
2024-10-26 @ 1:32 PM
Study NCT ID:
NCT04337268
Status:
COMPLETED
Last Update Posted:
2020-04-07
First Post:
2020-03-29
Brief Title:
Acute Effects of GLP-1 on Renal Hemodynamics
Sponsor:
Rigshospitalet Denmark
Organization:
Rigshospitalet Denmark
Study Overview
Official Title:
Acute Effects of GLP-1 on Renal Hemodynamics Simultaneous Perfusion and Oxygenation Measurements in Cortex and Medulla Using Magnetic Resonance Imaging
Status:
COMPLETED
Status Verified Date:
2020-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
GLP1RRBF
Brief Summary:
This study investigates the hypothesis that GLP-1s suppression of ANG II and natriuretic action increase medullary perfusion and decrease oxygen consumption leading to higher tissue oxygenation
Detailed Description:
Human studies have recently demonstrated a significant natriuretic effect of GLP-1 when the extracellular fluid volume ECFV is expanded by intravenous sodium-loading in these studies there was a suppression of ANG II with no change in net renal hemodynamics pointing to a tubular mechanism for reduced NaCl reabsorption secondary to the ANG II suppression In the current randomized and controlled study investigators aim to test the hypothesis that GLP-1s suppression of ANG II and natriuretic action increase medullary perfusion and decrease oxygen consumption leading to higher tissue oxygenation Thus contributing to the renoprotective action of GLP-1
Under fixed sodium intake for 4 days before each study day 10 healthy male participants will be investigated during a 1-hour infusion of GLP-1 15 pmolkgmin or vehicle together with an intravenous infusion of 09 NaCl Interleaved measurements of RAF oxygenation T2 and perfusion by arterial spin labeling in the renal cortex and medulla at fixed time points will be conducted using Magnetic Resonance Imaging MRI
Under fixed sodium intake for 4 days before each study day 10 healthy male participants will be investigated during a 1-hour infusion of GLP-1 15 pmolkgmin or vehicle together with an intravenous infusion of 09 NaCl Interleaved measurements of RAF oxygenation T2 and perfusion by arterial spin labeling in the renal cortex and medulla at fixed time points will be conducted using Magnetic Resonance Imaging MRI
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None