Ignite Creation Date:
2024-05-06 @ 2:30 PM
Last Modification Date:
2024-10-26 @ 1:32 PM
Study NCT ID:
NCT04333186
Status:
COMPLETED
Last Update Posted:
2020-11-10
First Post:
2020-03-29
Brief Title:
Expiratory Muscle Function in Critically Ill Ventilated Patients
Sponsor:
Amsterdam UMC location VUmc
Organization:
Amsterdam UMC location VUmc
Study Overview
Official Title:
Expiratory Muscle Function in Critically Ill Ventilated Patients
Status:
COMPLETED
Status Verified Date:
2020-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
EMFIC
Brief Summary:
Inspiratory muscle weakness develops rapidly in ventilated critically ill patients and is associated with adverse outcome including prolonged duration of mechanical ventilation and mortality Surprisingly the effects of critical illness on expiratory muscle function have not been studied
The main expiratory muscles are the abdominal wall muscles including the external oblique EO internal oblique IO and transversus abdominis muscles TRA These muscles are activated when respiratory drive or load increases which can be during eg exercise diaphragm fatigue increased airway resistance or positive airway pressure ventilation The abdominal wall muscles are also critical for protective reflexes such as coughing Reduced abdominal muscles strength may lead to decreased cough function and thus inadequate airway clearance This will lead to secretion pooling in the lower airways atelectasis and ventilator associated pneumonia VAP Studies have shown that decreased cough function is a risk for weaning failure and rehospitalization for respiratory complications Further high mortality was found in patients with low peak expiratory flow
Considering the importance of a proper expiratory muscle function in critically ill patients it is surprising that the prevalence causes and functional impact of changes in expiratory abdominal muscles thickness during mechanical ventilation MV for critically ill patients are still unknown
Ultrasound is increasingly used in the ICU for the visualization of respiratory muscles In a recent pilot study the investigators confirmed the feasibility and reliability of using of ultrasound to evaluate both diaphragm and expiratory abdominal muscle thickness in ventilated critically ill patients manuscript in preparation Accordingly the primary aim of the present study is to evaluate the evolution of abdominal expiratory muscle thickness during MV in adult critically ill patients using ultrasound data
The main expiratory muscles are the abdominal wall muscles including the external oblique EO internal oblique IO and transversus abdominis muscles TRA These muscles are activated when respiratory drive or load increases which can be during eg exercise diaphragm fatigue increased airway resistance or positive airway pressure ventilation The abdominal wall muscles are also critical for protective reflexes such as coughing Reduced abdominal muscles strength may lead to decreased cough function and thus inadequate airway clearance This will lead to secretion pooling in the lower airways atelectasis and ventilator associated pneumonia VAP Studies have shown that decreased cough function is a risk for weaning failure and rehospitalization for respiratory complications Further high mortality was found in patients with low peak expiratory flow
Considering the importance of a proper expiratory muscle function in critically ill patients it is surprising that the prevalence causes and functional impact of changes in expiratory abdominal muscles thickness during mechanical ventilation MV for critically ill patients are still unknown
Ultrasound is increasingly used in the ICU for the visualization of respiratory muscles In a recent pilot study the investigators confirmed the feasibility and reliability of using of ultrasound to evaluate both diaphragm and expiratory abdominal muscle thickness in ventilated critically ill patients manuscript in preparation Accordingly the primary aim of the present study is to evaluate the evolution of abdominal expiratory muscle thickness during MV in adult critically ill patients using ultrasound data
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None