Ignite Creation Date:
2024-05-05 @ 5:06 PM
Last Modification Date:
2024-10-26 @ 9:27 AM
Study NCT ID:
NCT00382382
Status:
WITHDRAWN
Last Update Posted:
2015-03-13
First Post:
2006-09-28
Brief Title:
Diffusion Tensor Imaging in Autism
Sponsor:
University of Florida
Organization:
University of Florida
Study Overview
Official Title:
Diffusion Tensor Imaging in Autism
Status:
WITHDRAWN
Status Verified Date:
2015-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Study was completed but there were no participants It was completed as a theoretical study Requests for final progress report can be sent to Dr Liu
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Using a new and more detailed approach to diffusion tensor imaging DTI recently developed in our lab the investigators hope to learn more about irregularities in the brain that are related to autism The investigators are especially interested in brain regions that contribute to repetitive behaviors in children with autism Repetitive behaviors include stereotyped motor movements hand-flapping self-injurious behaviors head hitting compulsions lining up toys insistence on things staying the same and difficulty with change These behaviors often interfere with learning can disrupt daily functioning and can lead to other behavioral problems Two specific aims will be accomplished
Aim 1 To examine the integrity of white matter pathways in high functioning autistic children The investigators hypothesize that autism is associated with specific white matter abnormalities in the cerebellum and other motor circuits Additionally the investigators expect to confirm and expand on previous reports of cerebral abnormalities by using newly developed DTI methods
Aim 2 To determine whether there is a relationship between white matter abnormalities and the occurrence of restricted repetitive behaviors in children with autism The investigators hypothesize that differences in the occurrence and type of restricted repetitive behaviors between autistic individuals are correlated with specific regional white matter abnormalities
Results from the proposed experiments should contribute to current knowledge of brain abnormalities in autism and their relationship to restricted repetitive behaviors and may be relevant to understanding the mechanisms underlying motor deficits in this disorder
Aim 1 To examine the integrity of white matter pathways in high functioning autistic children The investigators hypothesize that autism is associated with specific white matter abnormalities in the cerebellum and other motor circuits Additionally the investigators expect to confirm and expand on previous reports of cerebral abnormalities by using newly developed DTI methods
Aim 2 To determine whether there is a relationship between white matter abnormalities and the occurrence of restricted repetitive behaviors in children with autism The investigators hypothesize that differences in the occurrence and type of restricted repetitive behaviors between autistic individuals are correlated with specific regional white matter abnormalities
Results from the proposed experiments should contribute to current knowledge of brain abnormalities in autism and their relationship to restricted repetitive behaviors and may be relevant to understanding the mechanisms underlying motor deficits in this disorder
Detailed Description:
Using a new and more detailed approach to diffusion tensor imaging DTI recently developed in our lab the investigators aim to confirm and expand upon previous findings of white matter abnormalities throughout the brain in individuals with autism The investigators have chosen to focus particularly on cerebellar and motor pathways in consideration of the prevalence of motor deficits in autism as well as brain structural studies that have indicated cerebellar abnormalities in autistic children Finally a proposal to investigate a possible functional association between white matter structure and the expression of restricted repetitive behaviors in autistic children by correlating measures of white matter integrity with behavioral assessments indicating the severity of various forms of restricted repetitive behaviors Two specific aims will be accomplished Aim 1 To examine the integrity of white matter pathways in high functioning autistic children The hypothesis is that autism is associated with specific white matter abnormalities in the cerebellum and other motor circuits Additionally it is expect to confirm and expand on previous reports of cerebral abnormalities by using newly developed DTI methods Aim 2 To determine whether there is a relationship between white matter abnormalities and the occurrence of restricted repetitive behaviors in children with autism The hypothesis is that differences in the occurrence and type of restricted repetitive behaviors between autistic individuals are correlated with specific regional white matter abnormalities Results from the proposed experiments should contribute to current knowledge of brain abnormalities in autism and their relationship to restricted repetitive behaviors and may be relevant to understanding the mechanisms underlying motor deficits in this disorder
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None