Ignite Creation Date:
2024-05-06 @ 2:25 PM
Last Modification Date:
2024-10-26 @ 1:30 PM
Study NCT ID:
NCT04313530
Status:
UNKNOWN
Last Update Posted:
2022-04-06
First Post:
2020-03-16
Brief Title:
TMS Treatment in Multiple System Atrophy With Fatigue
Sponsor:
Xuanwu Hospital Beijing
Organization:
Xuanwu Hospital Beijing
Study Overview
Official Title:
Study on the Effect and Mechanism of Transcranial Magnetic Stimulation in Multiple System Atrophy Patients With Fatigue
Status:
UNKNOWN
Status Verified Date:
2022-03
Last Known Status:
ENROLLING_BY_INVITATION
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
TMSMSAF
Brief Summary:
Transcranial magnetic stimulation TMS is a procedure that has been shown to improve fatigue in chronic sufferers It uses a plastic covered coil that sends a magnetic pulse through the skull into the brain and by targeting particular areas in the brain it can be used to help modulate the perception of fatigue
The study intends to use this technique to treat such a disabling symptom in patients who suffer from Multiple System Atrophy MSA Initially the aim is to study this technique in 22 MSA patients who are suffering from fatigue These patients would require an resting-state funtional MRI before and after the stimulation The stimulation would be performed ten sessions and the patients would be assessed by a clinician using well recognized clinical tools
It is anticipated that there will be a meaningful improvement in fatigue It is also anticipated that TMS is a safety technique to use in MSA patients Our findings will revealed that fatigue may be associated with an altered default mode network and sensorimotor network connectivity in MSA patients We hypothesize that these divergent motor and cognitive networks connectivity changes and their adaptive or maladaptive functional outcome may play a prominent role in the pathophysiology of fatigue in MSA
The study intends to use this technique to treat such a disabling symptom in patients who suffer from Multiple System Atrophy MSA Initially the aim is to study this technique in 22 MSA patients who are suffering from fatigue These patients would require an resting-state funtional MRI before and after the stimulation The stimulation would be performed ten sessions and the patients would be assessed by a clinician using well recognized clinical tools
It is anticipated that there will be a meaningful improvement in fatigue It is also anticipated that TMS is a safety technique to use in MSA patients Our findings will revealed that fatigue may be associated with an altered default mode network and sensorimotor network connectivity in MSA patients We hypothesize that these divergent motor and cognitive networks connectivity changes and their adaptive or maladaptive functional outcome may play a prominent role in the pathophysiology of fatigue in MSA
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None