Ignite Creation Date:
2024-05-05 @ 11:19 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001415
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Glucocorticoid Effects on Cellular Cytokine Release
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Glucocorticoid Effects on Cellular Cytokine Release
Status:
COMPLETED
Status Verified Date:
1999-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
A variety of hormones and immune system processes are responsible for how the body responds to illness This study concentrates on how the hormone cortisol effects the release of immune system factors called cytokines
Cortisol is a hormone produced in the adrenal glands as a response to stimulation from the pituitary gland Abnormal levels of cortisol have been seen in several diseases such as depression and multiple sclerosis
Cytokines are factors produced by certain white blood cells They act by changing the cells that produce them autocrine effect altering other cells close to them paracrine and effecting cells throughout the body endocrine effect Cytokines are important in controlling inflammation processes
In this study researchers would like to determine if changes in levels of hormones in the blood are associated with changes in cytokine levels In addition researchers would like to learn more about how cytokines respond to hormones in certain diseases
Cortisol is a hormone produced in the adrenal glands as a response to stimulation from the pituitary gland Abnormal levels of cortisol have been seen in several diseases such as depression and multiple sclerosis
Cytokines are factors produced by certain white blood cells They act by changing the cells that produce them autocrine effect altering other cells close to them paracrine and effecting cells throughout the body endocrine effect Cytokines are important in controlling inflammation processes
In this study researchers would like to determine if changes in levels of hormones in the blood are associated with changes in cytokine levels In addition researchers would like to learn more about how cytokines respond to hormones in certain diseases
Detailed Description:
Many of the biochemical alterations observed in people suffering from major depression are changes in the concentrations and activity of components of the generalized stress response These include the principal hypothalamic stimulus of pituitary-adrenal activation corticotropin releasing hormone and the locus ceruleusnorepinephrine system The current study attempts to provide a clearer picture of the stability of changes during the acute illness the treatment phase and the recovery process We particularly wish to determine whether abnormalities in HPA axis perturbability in the well-state can be demonstrated and if so how these are related to the acutely-ill state since this information could provide a quantifiable phenotypic marker for depression
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 94-M-0146 | None | None | None |