Ignite Creation Date:
2024-05-05 @ 5:04 PM
Last Modification Date:
2024-10-26 @ 9:28 AM
Study NCT ID:
NCT00384566
Status:
WITHDRAWN
Last Update Posted:
2015-06-24
First Post:
2006-10-05
Brief Title:
A Comparison of the Effect of Carvedilol and Metoprolol on Airways Tone in Patients With Heart Failure
Sponsor:
The Alfred
Organization:
The Alfred
Study Overview
Official Title:
The CAMERA Study CArvedilol MEtoprolol Respiratory Assessment Investigator Trial
Status:
WITHDRAWN
Status Verified Date:
2015-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
In order to join forces with another study already running which aims to answer the same question
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study looks at the effect of two drugs carvedilol and metoprolol which are used for patients with CHF chronic heart failure
These agents are beta-blockers and although effective in heart failure may cause increases in airways tone and thus limit air getting into the lower parts of the lungs Carvedilol is more active at blocking the receptor that opens up the airways and therefore theoretically may be more likely to reduce airways tone than metoprolol although this has never been studied in patients with heart failure and that is the purpose of the present study
We are looking to enrol 45 patients with heart failure and mild obstruction to the flow of air in their lungs Patients will be randomised to either carvedilol or metoprolol standard doses Following a minimum of 2 weeks of therapy of study medication the patient will undergo a study day involving an assessment of their lung function an assessment of their heart failure a living with heart failure questionnaire blood tests and blood pressure and heart rate readings
Patients will then be crossed over to the alternate medication Following 2 weeks on the target dose the patient will undergo their second study day which will be the same as the first
The results obtained from each study day will be compared
These agents are beta-blockers and although effective in heart failure may cause increases in airways tone and thus limit air getting into the lower parts of the lungs Carvedilol is more active at blocking the receptor that opens up the airways and therefore theoretically may be more likely to reduce airways tone than metoprolol although this has never been studied in patients with heart failure and that is the purpose of the present study
We are looking to enrol 45 patients with heart failure and mild obstruction to the flow of air in their lungs Patients will be randomised to either carvedilol or metoprolol standard doses Following a minimum of 2 weeks of therapy of study medication the patient will undergo a study day involving an assessment of their lung function an assessment of their heart failure a living with heart failure questionnaire blood tests and blood pressure and heart rate readings
Patients will then be crossed over to the alternate medication Following 2 weeks on the target dose the patient will undergo their second study day which will be the same as the first
The results obtained from each study day will be compared
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None