Ignite Creation Date:
2024-05-06 @ 2:16 PM
Last Modification Date:
2024-10-26 @ 1:28 PM
Study NCT ID:
NCT04267406
Status:
COMPLETED
Last Update Posted:
2020-02-12
First Post:
2020-02-07
Brief Title:
ADAMTS-13 and Von Willebrand Factor Levels and Activities in Children With Cirrhosis andor Portal Hypertension
Sponsor:
Ataturk University
Organization:
Ataturk University
Study Overview
Official Title:
Investigation of Changes in ADAMTS-13 and Von Willebrand Factor Levels and Activities in Children With Cirrhosis andor Portal Hypertension
Status:
COMPLETED
Status Verified Date:
2020-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Hemostasis-related disorders are common in cirrhosis and portal hypertension However it is not known whether the net effect of changes in hemostasis in the sense of predisposition to hemorrhagic or thrombotic state It is suggested that increasing the concentration and activities of Von Willebrand factor vWF and decline ADAMTS-13 A Disintegrin and Metalloproteinase with Trombospondin type 1 motif member 13 may cause thrombophilic changes in cirrhosis and portal hypertension The aim of this study was to investigate the changes in ADAMTS-13 A disintegrin and metalloproteinase with thrombospondin motifs 13 and von willebrand factor vWF levels and activities in patients with cirrhosis and portal hypertension
Detailed Description:
Patients of 3 months to 18 years of age followed-up or newly diagnosed in pediatric gastroenterology unit who had cirrhosis or non cirrhotic portal hypertension included to the study Written informed consent obtained from the parents andor patients The subjects was grouped in three The first group consisted of patients with cirrhosis with or without portal hypertension The second group consisted of patients with non-cirrhotic portal hypertension developed due thrombosis of portal vein The last group consisted of healthy volunteers
2 ml of EDTA blood was taken from the patients and healty volunters Samples will be tested for vWF and ADAMTS-13 levels and activities at the end of the study
The clinical scoring methods PELD MELD and Child Pugh scores treatments received by patients data from endoscopic radiological screening and blood analysis of patients were recorded
2 ml of EDTA blood was taken from the patients and healty volunters Samples will be tested for vWF and ADAMTS-13 levels and activities at the end of the study
The clinical scoring methods PELD MELD and Child Pugh scores treatments received by patients data from endoscopic radiological screening and blood analysis of patients were recorded
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None