Ignite Creation Date:
2024-05-06 @ 2:14 PM
Last Modification Date:
2024-10-26 @ 1:27 PM
Study NCT ID:
NCT04254146
Status:
UNKNOWN
Last Update Posted:
2020-06-18
First Post:
2020-01-31
Brief Title:
Effects of Acute Exercise on BDNF Levels in Rheumatoid Arthritis Patients
Sponsor:
Gazi University
Organization:
Gazi University
Study Overview
Official Title:
Effects of Acute Exercise on BDNF Levels in Rheumatoid Arthritis Patients
Status:
UNKNOWN
Status Verified Date:
2020-06
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background RA may progress with articular and non-articular involvementDepression prevelance is found to increase for RA patients according to healthy population and to be correlated with pain decreased quality of life fatigue and physical disabilityBDNF level was found significantly lower in RA patients with depression Aim of this study is to investigate the variation of BDNF levels following acute exercise and potential correlation between BDNF levels and depression
Methods This study included 30 RA patients and 30 age and sex matched healthy controlsDepression levels were evaluated with Beck Depression Inventory BDI and Hospital Anxiety and Depression Scale HADS Blood samples from all subjects were taken and centrifuged before and immediately after the exercise intervention
Methods This study included 30 RA patients and 30 age and sex matched healthy controlsDepression levels were evaluated with Beck Depression Inventory BDI and Hospital Anxiety and Depression Scale HADS Blood samples from all subjects were taken and centrifuged before and immediately after the exercise intervention
Detailed Description:
Background Rheumatoid Arthritis RA is a chronic inflammatory rheumatic disease that genetic and environmental factors play role in its pathogenesis There may be other symptoms caused by both the inflammation and the chronic disease effect as well as the symptoms associated with the disease such as depression fatigue physical inactivity and decreased quality of life Major depression risk was revealed 168 of RA patients in a meta-analysis Depression prevalence was found 388 by the assessment with Patient Health Questionnaire PHQ-9 and between 148 and 48 by the assessment with Hospital Anxiety and Depression Scale BDNF is a neurotrofic factor that may show healing survival-promoting and protective effects on neurons in central and peripheral nervous system Acute or chronic exercise programmes were found to increase BDNF levels in human and animal studies Aim of this study is to investigate the variation of BDNF levels following acute exercise and potential correlation between BDNF levels and depression
Methods This study included 30 RA patients and 30 age and sex matched healthy controlsPatients who were aged between 18-65 years got diagnosed according to American College of Rheumatology criteria and were being followed at Firat University Department of Rheumatology were included in the study Also patients who had regular exercise habits malignancy pregnancy incorporation took anti-TNF treatment had changes of medical treatment in last 3 months diagnosed with Fibromyalgia Syndrome and Osteoarthritis for lower extremity had cardiac symptoms according to New York Heart Association and had dysfunction that can prevent physical activity were excluded from the study Healthy participants who were aged 18- 65 years old and not to have exercise habits were included in this study Participants included in the study were asked and recorded age body mass index BMI smoking alcohol habits duration of the disease vocation and having another chronic disease Next depression levels were evaluated with Beck Depression Inventory BDI and Hospital Anxiety and Depression Scale HADS Blood samples from all subjects were taken and centrifuged before and immediately after the exercise interventionAerobic exercise was performed to all participants for a single session Maximum heart rate was calculated for each subject 220 - age and a heart rate monitor Polar FT 100 China was used to follow subjects heart rate during aerobic exercise
Methods This study included 30 RA patients and 30 age and sex matched healthy controlsPatients who were aged between 18-65 years got diagnosed according to American College of Rheumatology criteria and were being followed at Firat University Department of Rheumatology were included in the study Also patients who had regular exercise habits malignancy pregnancy incorporation took anti-TNF treatment had changes of medical treatment in last 3 months diagnosed with Fibromyalgia Syndrome and Osteoarthritis for lower extremity had cardiac symptoms according to New York Heart Association and had dysfunction that can prevent physical activity were excluded from the study Healthy participants who were aged 18- 65 years old and not to have exercise habits were included in this study Participants included in the study were asked and recorded age body mass index BMI smoking alcohol habits duration of the disease vocation and having another chronic disease Next depression levels were evaluated with Beck Depression Inventory BDI and Hospital Anxiety and Depression Scale HADS Blood samples from all subjects were taken and centrifuged before and immediately after the exercise interventionAerobic exercise was performed to all participants for a single session Maximum heart rate was calculated for each subject 220 - age and a heart rate monitor Polar FT 100 China was used to follow subjects heart rate during aerobic exercise
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None