Ignite Creation Date:
2024-05-05 @ 5:04 PM
Last Modification Date:
2024-10-26 @ 9:27 AM
Study NCT ID:
NCT00371163
Status:
COMPLETED
Last Update Posted:
2015-04-22
First Post:
2006-08-30
Brief Title:
Molecular and Cellular Characterization of Spongiotic Dermatitis
Sponsor:
University of California Davis
Organization:
University of California Davis
Study Overview
Official Title:
Molecular and Cellular Characterization of Spongiotic Dermatitis
Status:
COMPLETED
Status Verified Date:
2015-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Spongiotic
Brief Summary:
Spongiotic dermatitis is the histopathologic diagnosis commonly issued by dermatopathologists that encompasses atopic dermatitis contact dermatitis and other forms of eczematous dermatitis
The information obtained will assist in development of diagnostic methods for differentiation of the types of spongiotic dermatitis This study also has the potential to lead to the dissection of pathologic pathways involved in these diseases and development of novel therapeutic agents
The information obtained will assist in development of diagnostic methods for differentiation of the types of spongiotic dermatitis This study also has the potential to lead to the dissection of pathologic pathways involved in these diseases and development of novel therapeutic agents
Detailed Description:
Spongiotic dermatitis is the histopathologic diagnosis commonly issued by dermatopathologists that encompasses atopic dermatitis contact dermatitis and other forms of eczematous dermatitis Atopic dermatitis is a chronic relapsing inflammatory disease characterized by pruritic scaly red eczematous skin lesions and a personal or family history of atopy Patients affected by atopic dermatitis experience significant morbidity from extreme pruritus recurrent cutaneous infections and extensive andor disfiguring skin lesions Allergic contact dermatitis typically manifests as pruritus and vesicular or eczematous lesions associated with direct exposure to environmental haptenic allergens
The specific aims of this research are
1 Identification of genes differentially expressed in atopic dermatitis contact dermatitis and psoriasis by microarray analyses
2 Confirmation of protein expression profiles in atopic and contact dermatitis and psoriasis by immunohistochemical analyses
3 Identification of disease-specific potential diagnostic markers in plasma and PBMC
The information obtained will assist in development of diagnostic methods for differentiation of the types of spongiotic dermatitis This study also has the potential to lead to the dissection of pathologic pathways involved in these diseases and development of novel therapeutic agents
The specific aims of this research are
1 Identification of genes differentially expressed in atopic dermatitis contact dermatitis and psoriasis by microarray analyses
2 Confirmation of protein expression profiles in atopic and contact dermatitis and psoriasis by immunohistochemical analyses
3 Identification of disease-specific potential diagnostic markers in plasma and PBMC
The information obtained will assist in development of diagnostic methods for differentiation of the types of spongiotic dermatitis This study also has the potential to lead to the dissection of pathologic pathways involved in these diseases and development of novel therapeutic agents
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None