Ignite Creation Date:
2024-05-05 @ 5:04 PM
Last Modification Date:
2024-10-26 @ 9:27 AM
Study NCT ID:
NCT00375336
Status:
UNKNOWN
Last Update Posted:
2009-01-01
First Post:
2006-09-11
Brief Title:
Risk Factors Associated With Calcification of the Aortic Valve
Sponsor:
Charles University Czech Republic
Organization:
Charles University Czech Republic
Study Overview
Official Title:
Risk Markers of Coronary Artery Disease Associated With Calcific Aortic Valve Disease
Status:
UNKNOWN
Status Verified Date:
2008-12
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is
to determine the degree of endothelial dysfunction and inflammation in calcific aortic valve disease associated with coronary artery diseaseCAD
to determine whether there is relationship between calcium metabolism and calcific aortic valve disease associated with CAD
to determine the degree of endothelial dysfunction and inflammation in calcific aortic valve disease associated with coronary artery diseaseCAD
to determine whether there is relationship between calcium metabolism and calcific aortic valve disease associated with CAD
Detailed Description:
Cardiovascular disease mainly coronary artery disease causes more than one half of deaths in the developed countries Only recently calcific aortic valve disease was proved to belong to the family of atherosclerosis It is associated with higher cardiovascular morbidity and mortality the cause of which is not entirely clear The link to significant coronary artery disease probably is of highest importance
We compare groups of patients with coronary artery disease and calcific stenotic sclerotic or intact aortic valve The aim is to assess and compare their risk profile to verify our hypothesis that within significant coronary artery disease calcific aortic valve identifies a subgroup of patients with higher cardiovascular risk assessed by endothelial dysfunction and the two year follow-up of cardiovascular events on optimally set treatment
Further we study the possible association of valvular calcification and calcium metabolism in patients with normal kidney function
We compare groups of patients with coronary artery disease and calcific stenotic sclerotic or intact aortic valve The aim is to assess and compare their risk profile to verify our hypothesis that within significant coronary artery disease calcific aortic valve identifies a subgroup of patients with higher cardiovascular risk assessed by endothelial dysfunction and the two year follow-up of cardiovascular events on optimally set treatment
Further we study the possible association of valvular calcification and calcium metabolism in patients with normal kidney function
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None