Ignite Creation Date:
2024-05-06 @ 2:12 PM
Last Modification Date:
2024-10-26 @ 1:26 PM
Study NCT ID:
NCT04244526
Status:
UNKNOWN
Last Update Posted:
2020-01-30
First Post:
2020-01-25
Brief Title:
Urinary Tract Infection in Pregnancy
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Distribution of Virulence Genes and Their Association With Clinical Presentation of Urinary Tract Infection and Antimicrobial Resistance Among Uropathogenic Escherichia Coli Isolated From Pregnant Women
Status:
UNKNOWN
Status Verified Date:
2020-01
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
to describe the profile of uropathogenic E coli from Egyptian pregnant women with UTIs and a symptomatic bacteriuria
to determine the susceptibility pattern of our local isolated UPEC strains which is essential for optimal management of UTI
to evaluate the different virulence genes in UPEC isolates and their association with antibiotic resistance
to track common UPEC serogroups
to investigate the biofilm formation and the relationship between virulence genes and biofilm formation in UPEC strains isolated from patients
to determine the susceptibility pattern of our local isolated UPEC strains which is essential for optimal management of UTI
to evaluate the different virulence genes in UPEC isolates and their association with antibiotic resistance
to track common UPEC serogroups
to investigate the biofilm formation and the relationship between virulence genes and biofilm formation in UPEC strains isolated from patients
Detailed Description:
Urinary tract infection represents the most common bacterial infection in pregnancy and the third common cause of human infection after respiratory and intestinal infections The infection can be life threatening and associated with serious complications UTI can be associated with defined symptomssymptomatic or without symptoms asymptomatic Asymptomatic bacteriuria is defined as the presence of 100000 colony forming unitsml of urine of a single pathogen in two consecutive midstream clean catch urine specimen or on catheterization specimen from an individual without signs or symptoms associated with urinary or genital organs Asymptomatic bacteriuria can lead to acute pyelonephritis in30of pregnant women and complications such as early delivery increase risk of hypertension pre-eclampsia low birth weight and postpartum endometritis Ecoli accounts for most cases of symptomatic and asymptomatic bacteriuria in women representing70 _90 of the cases The important virulence factors of uropathogenic ecoli can be broadly divided into two groups bacterial cell surface factors and secreted factors The emergence of drug resistant microorganism among Uropathogenic Escherichia coli strains increases the serious threat to global health Ecoli often acquired genes coding for antibiotic resistance beta-lactamase enzymes are the most frequent and play a key role conferring resistance of bacteria to beta lactam antibiotic group such as penicillin and cephalosporins Therefore knowledge regarding local prevalence of uropathogenic ecoli and antimicrobial resistance is essential for optimal management of UTI
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None