Ignite Creation Date:
2024-05-06 @ 2:11 PM
Last Modification Date:
2024-10-26 @ 1:27 PM
Study NCT ID:
NCT04247698
Status:
UNKNOWN
Last Update Posted:
2020-01-31
First Post:
2020-01-28
Brief Title:
Hemodynamic Forces at Rest and Stress vs Adenosine and Dobutamine Stress Cardiac Magnetic Resonance
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Prognostic Value of Hemodynamic Forces at Rest and Stress Compared to Adenosine and Dobutamine Stress Cardiac Magnetic Resonance
Status:
UNKNOWN
Status Verified Date:
2020-01
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
CMR
Brief Summary:
Stress perfusion CMR has recently considered as one of the methods of choice for establishing the diagnosis of CAD based on its high diagnostic accuracy lack of ionizing radiation as well as its ability to simultaneously assess the cardiac function myocardial perfusion and viability however there are some concerns on its suitability for assessment of myocardial perfusion in patients after coronary artery bypass graft surgery who suffer from recurrent angina The study of hemodynamic forces offers a promising tool for further understanding of the interplay between the myocardium and blood as well as the mechanisms of cardiac filling This work represents a retrospective follow up study of CMR data available on CMR-database from 112 patients with previous coronary artery bypass grafting CABG performed around 10 years before the initial CMR examination The study subjects underwent stress CMR testing using both stressors dobutamine and adenosine done on two separate occasions Injection of gadolinium contrast medium for late gadolinium enhancement was done with adenosine stress testing for late gadolinium enhancement LGE Offline analysis of these data will be done with the use of dedicated software for assessment for myocardial ischemia together with quantitative measurements of the hemodynamic forces with the help of dedicated software QStrain version 13079 Medis Leiden the Netherlands
Detailed Description:
In total 112 patients who underwent coronary artery bypass surgery CABG subjected to stress CMR examination on two separate occasions with both stressors dobutamine and adenosine for assessment of myocardial ischemia as result of typical atypical angina pectoris The results from dobutamine namely detection of wall motion abnormalities and adenosine stress CMR namely detection of perfusion abnormalities will be compared with the values obtained from the measures of the hemodynamic forces of the LV ie changes in the intraventricular pressures during systole and diastole The dimensionless root mean square FRMS is computed over the entire heartbeat as a measure of the overall force amplitude In addition LV global longitudinal strain GLS and LV global circumferential strain GCS will be measured using a CMR feature tracking techniques The expected results are as follows Dobutamine wall motion analysis in combination with perfusion imaging has the highest diagnostic accuracy for the detection of ischemia in patients after bypass surgery and outperforms pure dobutamine wall motion or perfusion analysis and adenosine perfusion Whereas perfusion imaging with both stressors reflects the extent of ischemia more precisely than wall motion analysis Nevertheless assessment of hemodynamic forces adds to the diagnostic accuracy as well as the prognostic value of stress CMR in post-CABG patients in whom stress testing with either or both stressors might fail to precisely define myocardial ischemia or reflect an associated subtle cardiac dysfunction
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None