Ignite Creation Date:
2024-05-05 @ 5:03 PM
Last Modification Date:
2024-10-26 @ 9:27 AM
Study NCT ID:
NCT00374127
Status:
COMPLETED
Last Update Posted:
2017-09-01
First Post:
2006-09-07
Brief Title:
Comparison Between Marijuana Smoked in Cigarette Paper Versus Cigar Paper
Sponsor:
New York State Psychiatric Institute
Organization:
New York State Psychiatric Institute
Study Overview
Official Title:
Comparison Between Marijuana Smoked in Cigarette Paper Joints Versus Cigar Paper Blunts
Status:
COMPLETED
Status Verified Date:
2017-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to investigate whether or not marijuana blunts will produce comparable plasma THC levels as marijuana joints and if blunts will produce larger cardiovascular and subjective effects
Detailed Description:
There has been a rapid increase in marijuana use during the 1990s with the most recent generation often smoking marijuana in the form of blunts as opposed to more traditional routes such as in pipes or in cigarette paper A blunt is made by removing the tobacco from a cigar and replacing it with marijuana Golub and Johnson 1999 The cigar wrapper contains tobacco and nicotine which may interact with the cardiovascular and subjective effects of the marijuana to produce a different set of effects and risks than cigarette paper Anecdotally marijuana smokers report that blunts are more potent than joints yet there have been no controlled studies addressing whether blunts enhance the subjective-effects and health-related consequences of marijuana use We are proposing to do a within-subject placebo-controlled study directly comparing the cardiovascular subjective and pharmacokinetic effects of marijuana smoked in blunts compared to identical quantities of marijuana smoked in cigarette paper Research volunteers will be current blunt smokers Each will participate in six 4-hour outpatient sessions After baseline data have been collected heart rate blood pressure mood scales exhaled carbon monoxide plasma THC and nicotine levels participants will take 3 puffs 5 seconds in duration from a NIDA marijuana cigarette containing 00 18 and 36 THC or from a blunt containing an equivalent quantity and strength of marijuana Participants will be blind to the type of marijuana cigarette smoked We will measure plasma THC and nicotine subjective mood ratings and heart rate and blood pressure repeatedly over the course of 180 minutes following smoking This study is the first controlled investigation of the consequences of this new method of marijuana smoking the data obtained may be useful in guiding future development of marijuana pharmacotherapy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None