Ignite Creation Date:
2024-05-06 @ 2:08 PM
Last Modification Date:
2024-10-26 @ 1:25 PM
Study NCT ID:
NCT04227223
Status:
COMPLETED
Last Update Posted:
2021-02-18
First Post:
2019-12-29
Brief Title:
Oxidative Balance in Opioid Therapy
Sponsor:
Medical University of Bialystok
Organization:
Medical University of Bialystok
Study Overview
Official Title:
Oxidative- Antioxidative Balance and Cognitive Functions During Opioid Therapy
Status:
COMPLETED
Status Verified Date:
2021-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The oxidative - antioxidative balance is the crucial mechanism of opioid-induced immunomodulation Additionally impairement of cognitive function during opioid therapy is another important side- effect This phenomenon was clearly described in opioids abuse This is interesting to evaluate the importance of this subjects in chronic pain patients The aim of the study was to investigate the oxidative - antioxidative homeostasis and cognitive functions using serum total oxidative capacity TOC and total antioxidative capacity TAC tests and Brain Derivered Neutrophic Factor BDNF in patient with chronic non-cancer pain treated with opioids
Detailed Description:
The project was approved in Ethical Committee and supported by Medical University of Bialystok Poland The serum TOC and TAC measurements were performed in total group of 50 adult patients Study Group - 36 patients with chronic Low-Back Pain with opioids pharmacotherapy and Control Group - 14 patients healthy volunteers In Study Group anthropometric parameters duration in opioid therapy type of opioid total dose and form of application were registeredTOC TAC and BDNF measurements were performed using ImAnOx PerOx BDNF tests Immundiagnostik GermanyData were analyzed using non-parametric tests
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None