Ignite Creation Date:
2024-05-06 @ 2:06 PM
Last Modification Date:
2024-10-26 @ 1:25 PM
Study NCT ID:
NCT04212858
Status:
UNKNOWN
Last Update Posted:
2019-12-30
First Post:
2019-12-23
Brief Title:
Amplification of Zinc Finger Protein 217 Gene in Multiple Myeloma
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Amplification of Zinc- Finger Protein 217 Gene in Multiple Myeloma Patients as a Prognostic Marker
Status:
UNKNOWN
Status Verified Date:
2019-12
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Multiple myeloma MM is blood disorder characterized by the detection of a monoclonal paraprotein in serum or urine which is often associated with the presence of clonal plasma cells PCs mainly in the bone marrow BM The zinc-finger protein 217 ZNF217 is an oncogenic protein that plays deleterious functions in various human cancers The ZNF217 gene is located at the 20q13 chromosomal region which is frequently amplified in human tumors
Detailed Description:
Multiple myeloma MM is blood disorder characterized by the detection of a monoclonal paraprotein in serum or urine which is often associated with the presence of clonal plasma cells PCs mainly in the bone marrow BM MM is the second most common hematologic malignancy and is expected to cause 13 000 new cases and 30 000 deaths in 2018 Myeloma is a genetically complex disorder characterized by multiple genetic changes affecting different pathways that have the ability to deregulate plasma cell biology leading to a broadly similar phenotypic manifestation of disease From a genetic perspective myeloma can be divided into those with and without a hyperdiploid karyotype The zinc-finger protein 217 ZNF217 is an oncogenic protein that plays deleterious functions in various human cancers The ZNF217 gene is located at the 20q13 chromosomal region which is frequently amplified in human tumors This region also contains several oncogenes thought to confer selective advantages to cancer cells Increased copy numbers of ZNF217 have been reported in various tumors and linked to poor outcome in some studies ZNF217 can attenuate apoptotic signals resulting from telomere dysfunction and may promote neoplastic transformation and later stages of malignancy ZNF217 was shown to be a prognostic biomarker and therapeutic target during breast cancer progression In our best knowledge No studies were done to detect ZNF217 in multiple myeloma
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None