Ignite Creation Date:
2024-05-05 @ 5:03 PM
Last Modification Date:
2024-10-26 @ 9:27 AM
Study NCT ID:
NCT00370630
Status:
UNKNOWN
Last Update Posted:
2007-02-21
First Post:
2006-08-31
Brief Title:
Intravitreal Avastin Versus Intravitreal Avastin and Triamcinolone in Central Retinal Vein OcclusionCRVO
Sponsor:
Shahid Beheshti University of Medical Sciences
Organization:
Shahid Beheshti University of Medical Sciences
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2007-02
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In this study we intend to evaluate and compare the outcomes of intravitreal avastin versus avastin and triamcinolone on improving the visual acuity and macular edema and late complications of CRVO like NVI and NVG
Detailed Description:
Central retinal vein occlusion CRVO is a common retinal vascular disorder with potentially complications like reduced vision resulting from extensive intraretinal hemorrhage retinal ischemia and persistent macular edema and neovascular glaucoma secondary to iris neovascularization Macular edema is a common cause of severe visual loss in both branch retinal vein occlusion BRVO and central retinal vein occlusion CRVO Natural history data indicate that CRVO patients presenting with poor visual acuity _20200 have an 80 chance of being left with visual acuity less than 20200 at final visit whether the CRVO is ischemic or nonischemic at presentation Treatments that target the secondary effects of venous occlusion such as grid laser photocoagulation for macular edema and prophylactic panretinal laser photocoagulation for nonperfused CRVO were shown to be ineffective in improving visual acuity in the Central Vein Occlusion Study CVOS Although panretinal photocoagulation is advocated for reducing the risk of neovascular glaucoma in patients with ischemic CRVO recent clinical trials have failed to demonstrate any significant benefit with laser photocoagulation in the treatment of macular edema due to CRVO A number of other treatment options are sometimes used in cases of CRVO such as oral corticosteroids intravitreal steroids vitrectomy hemodilution intravitreal tissue plasminogen activator hyperbaric oxygen and laser or surgical chorioretinal anastomosis Studies demonstrating the effectiveness of these treatments are inconclusive although some benefits have been suggested in recent reports In recent studies the benefit of antiVEGF agents in improving the macular edema due to CRVO have been shown In this study we are going to compare the effect of intravitreal antiVEGF Avastin with combination of Avastin and Triamcinolon in improving the visual acuity and macular thickness in patients with recent Less than 6 months CRVO
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None