Ignite Creation Date:
2024-05-05 @ 5:02 PM
Last Modification Date:
2024-10-26 @ 9:27 AM
Study NCT ID:
NCT00373880
Status:
COMPLETED
Last Update Posted:
2017-09-11
First Post:
2006-09-07
Brief Title:
Effects of Aripiprazole on Cocaine Craving and Self-Administration
Sponsor:
New York State Psychiatric Institute
Organization:
New York State Psychiatric Institute
Study Overview
Official Title:
Effects of Aripiprazole on Cocaine Craving and Self-Administration
Status:
COMPLETED
Status Verified Date:
2017-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to investigate whether aripiprazole will decrease cocaine self-administration subjective effects and cravings compared to placebo
Detailed Description:
Despite the recent increase in data about cocaines basic neurochemical mechanisms of action progress towards the development of an effective pharmacological treatment for cocaine abuse has been disappointing We are proposing to use our laboratory model of repeated dose cocaine self-administration to assess the potential efficacy of the novel antipsychotic aripiprazole Aripiprazole is a partial agonist at both the dopamine D2 receptor and at the serotonin 5HT1a receptor while antagonizing the 5HT2a receptor By functioning as a partial D2 agonist aripiprazole is hypothesized to function as a D2 antagonist during hypodopaminergic states such as during cocaine use while functioning as a D2 agonist during hypodopaminergic states such as during cocaine withdrawal This 42-day outpatientinpatientoutpatientinpatient protocol will evaluate the effects of aripiprazole maintenance 0 15 mgday on cocaine craving subjective effects and self-administration using a within-subjects design Non-treatment seeking cocaine abusers will be maintained outpatient for 16 days of dose maintenance prior to inpatient cocaine self-administration sessions During the inpatient phases volunteers will live on a hospital clinical research unit and will participate in laboratory sessions in which they will have the opportunity to choose between repeated doses of smoked cocaine and 5 In addition to measuring their cocaine self-administration we will measure the cardiovascular and subjective effects of cocaine under each aripiprazole maintenance condition
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None