Ignite Creation Date:
2024-05-06 @ 2:04 PM
Last Modification Date:
2024-10-26 @ 1:24 PM
Study NCT ID:
NCT04201912
Status:
COMPLETED
Last Update Posted:
2019-12-18
First Post:
2019-12-15
Brief Title:
Role of TLR2 and TLR4 in Stage 2 Periodontitis Patients
Sponsor:
Ajman University
Organization:
Ajman University
Study Overview
Official Title:
Role of TLR2 and TLR4 in Stage 2 Periodontitis Patients With and Without Type 2 Diabetes
Status:
COMPLETED
Status Verified Date:
2019-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In Health mucosal inflammation is prevented by TLR Toll like receptors that interact with Specific MAMP microbe associated molecular pattern Currently about 13TLRs have been identified Among them TLR2 and 4 recognize most organisms Periodontal disease is mixed infection resulting due to dysbiosis When aggravated by systemic disease the role of TLRs is detrimental for the overall state of periodontal apparatus Type 2 diabetes is one of the systemic disease which is seen a risk factor if uncontrolled can exaggerate the titer of TLR2 and TLR4 biomarkers Various studies have been evaluated to determine the role of TLRs in autoimmune and periodontal conditions The purpose of this study is to determine if both TLR2 and TLR4 play equal roles in periodontal disease and in cases where periodontal disease is complicated by the presence of systemic disease Individual role of TLR2 and TLR4 in active disease will help determine treatment strategies and will also be able to predict potential biomarker in disease
Detailed Description:
In Health mucosal inflammation is prevented by TLR Toll like receptors that interact with Specific MAMP microbe associated molecular pattern Currently about 13TLRs have been identified Among them TLR2 and 4 recognize most organisms Periodontal disease is mixed infection resulting due to dysbiosis When aggravated by systemic disease the role of TLRs is detrimental for the overall state of periodontal apparatus Type 2 diabetes is one of the systemic disease which is seen a risk factor if uncontrolled can exaggerate the titer of TLR2 and TLR4 biomarkers Various studies have been evaluated to determine the role of TLRs in autoimmune and periodontal conditions The purpose of this study is to determine if both TLR2 and TLR4 play equal roles in periodontal disease and in cases where periodontal disease is complicated by the presence of systemic disease Individual role of TLR2 and TLR4 in active disease will help determine treatment strategies and will also be able to predict potential biomarker in disease
Periodontal diseases are classified according to the American academy of periodontology as stage 1 2 34 according to severity and extent of the disease progression
Stage 2 periodontitis was selected as it is considered as an intermediary because CALclinical attachment loss was standardized at 3-4mmthis could reflect the progression of disease and its impact from a horizontal bone loss to a more oblique one if in case the dysbiosis persists
Periodontal diseases are classified according to the American academy of periodontology as stage 1 2 34 according to severity and extent of the disease progression
Stage 2 periodontitis was selected as it is considered as an intermediary because CALclinical attachment loss was standardized at 3-4mmthis could reflect the progression of disease and its impact from a horizontal bone loss to a more oblique one if in case the dysbiosis persists
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None