Ignite Creation Date:
2024-05-05 @ 11:19 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005682
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2000-05-25
Brief Title:
Aplastic Anemia Epidemiology Incidence and Case-control
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To conduct incidence and case-control studies of aplastic anemia in metropolitan Bangkok Thailand
Detailed Description:
BACKGROUND
Aplastic anemia a form of bone marrow failure is a disease of largely unknown cause except for the rare situations involving high doses of radiation Many agents have been mentioned in case reports to be associated with the development of aplastic anemia and include drugs chemicals pesticides radiation and viral infection Of these chloramphenicol phenylbutazone and insecticides are most frequently reported In the United States and other developed countries the disease prevalence is so low that too few cases occur to make an epidemiological study in a single city logistically feasible The Bangkok hospitalization rate for aplastic anemia was sufficient to conduct a case-control study Also a study conducted in this locale provided information on drugs and chemicals not commonly used in developed countries
DESIGN NARRATIVE
All aplastic anemia cases in metropolitan Bangkok were located and verified in the forty hospitals that agreed to participate in the study Incidence rates were calculated by age group and sex In the case-control study interviews were used to obtain comprehensive histories of drug chemical pesticide radiation viral infections and other exposures along with relevant demographic and medical history information in order to examine the association between and test hypotheses regarding suspected hazards and to estimate the risks of developing aplastic anemia The basic epidemiologic features of aplastic anemia were described by characterizing these patients in terms of standard demographic variables age race sex and medical history The degree of association between viral hepatitis and the development of aplastic anemia was estimated
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Aplastic anemia a form of bone marrow failure is a disease of largely unknown cause except for the rare situations involving high doses of radiation Many agents have been mentioned in case reports to be associated with the development of aplastic anemia and include drugs chemicals pesticides radiation and viral infection Of these chloramphenicol phenylbutazone and insecticides are most frequently reported In the United States and other developed countries the disease prevalence is so low that too few cases occur to make an epidemiological study in a single city logistically feasible The Bangkok hospitalization rate for aplastic anemia was sufficient to conduct a case-control study Also a study conducted in this locale provided information on drugs and chemicals not commonly used in developed countries
DESIGN NARRATIVE
All aplastic anemia cases in metropolitan Bangkok were located and verified in the forty hospitals that agreed to participate in the study Incidence rates were calculated by age group and sex In the case-control study interviews were used to obtain comprehensive histories of drug chemical pesticide radiation viral infections and other exposures along with relevant demographic and medical history information in order to examine the association between and test hypotheses regarding suspected hazards and to estimate the risks of developing aplastic anemia The basic epidemiologic features of aplastic anemia were described by characterizing these patients in terms of standard demographic variables age race sex and medical history The degree of association between viral hepatitis and the development of aplastic anemia was estimated
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL035068 | NIH | None | httpsreporternihgovquickSearchR01HL035068 |