Ignite Creation Date:
2024-05-05 @ 5:02 PM
Last Modification Date:
2024-10-26 @ 9:27 AM
Study NCT ID:
NCT00373399
Status:
COMPLETED
Last Update Posted:
2018-12-19
First Post:
2006-09-07
Brief Title:
Effects of Smoked Marijuana on Risk Taking and Decision Making Tasks
Sponsor:
New York State Psychiatric Institute
Organization:
New York State Psychiatric Institute
Study Overview
Official Title:
Acute Effects of Smoked Marijuana on Decision Making as Assessed by a Modified Gambling Task in Experienced Marijuana Users
Status:
COMPLETED
Status Verified Date:
2018-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to investigate the effects of smoked marijuana on both risk taking and decision making tasks
Detailed Description:
Cannabis abuse and dependence are the most prevalent drug use disorders in the United States Compton et al 2004 yet little is known about the factors contributing to successful marijuana treatment Previously we have shown that cognitive impairments in patients treated for substance disorders are associated with premature treatment dropout However little is known about whether such impairments are the result of drug use per se The objective of this within-subject study is to determine whether decision-making and risk-taking are affected by acute cannabis intoxication The Balloon Analogue Risk Task BART Lejuez et al 2002 assesses decision making in a context of increasing risk and the Iowa Gambling Task IGT Bechara et al 1994 tests the ability to balance immediate rewards against long-term negative consequences both tasks have strong face validity for evaluating cognitive deficits that may contribute to poor treatment outcome Research volunteers will be current marijuana smokers Each will participate in three 4-hour outpatient sessions in the Substance Use Research Center SURC in the Division of Substance Abuse at NYSPI They will smoke a different strength marijuana cigarette 00 198 39 THC in each session in counter-balanced order After baseline data have been collected risk taking and decision making behaviors heart rate blood pressure mood scales exhaled carbon monoxide participants will take 3-6 puffs 5 seconds in duration from a National Institute on Drug Abuse NIDA marijuana cigarette After smoking we will repeatedly re-assess risk taking and decision making abilities with the BART and IGT We will also measure subjective mood ratings heart rate and blood pressure repeatedly for 180 minutes following smoking This study is the first controlled investigation of the effects of smoked marijuana on both risk taking and decision making tasks The data obtained will be used to guide treatment development for marijuana use disorders
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| DA-03746 | OTHER_GRANT | National Institute on Drug Abuse | None |