Ignite Creation Date:
2024-05-06 @ 2:01 PM
Last Modification Date:
2024-10-26 @ 1:23 PM
Study NCT ID:
NCT04185753
Status:
UNKNOWN
Last Update Posted:
2019-12-04
First Post:
2019-11-27
Brief Title:
Chronotropic Incompetence During Exercise Testing in Obese Adolescents
Sponsor:
Hasselt University
Organization:
Hasselt University
Study Overview
Official Title:
Chronotropic Incompetence During Cardiopulmonary Exercise Testing in Obese Adolescents Associations With Caridometabolic Health
Status:
UNKNOWN
Status Verified Date:
2019-12
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In adolescents with obesity cardiopulmonary exercise testing CPET has become an important clinical examination providing valuable information with regard to the integrative exercise responses including the pulmonary cardiovascular and muscular systems
During CPET mechanical constraints in ventilation an elevated risk for hypoxia and chronotropic incompetence CI defined as the inability of the heart to increase its rate with increased activity or compromised cardiac function eg lowered heart rate HR recovery chronotropic index and stroke volume are often observed in obese adults Moreover several studies regarding exercise capacity and cardiopulmonary responses to maximal endurance exercise testing have been performed in obese adolescents Despite these previous investigations in obese adolescents it remains controversial whether cardiopulmonary disturbances can be observed consistently during CPET However a number of studies have reported a suboptimal response to exercise in particular a reduced peak heart rate HRpeak and peak cycling power output Wpeak Adult obesity modifies cardiac behavior including resting HR and CI which has a marked effect on exercise capacity Therefore chronotropic variables are the most important factors that affect exercise performance It has been shown that both peak and resting HR account for over forty percent of variability of exercise capacity Interestingly resting HR and HR response to exercise including a blunted HR increase low chronotropic index and HR recovery are important predictors of all-cause mortality and cardiovascular death at least in adults These changes in HR during and recovery from CPET are mediated by the balance between sympathetic and vagal activity of the autonomic nervous system Adverse cardiovascular outcomes associated with the metabolic syndrome may be mediated by autonomic dysfunction whereby obesity is characterized by sympathetic predominance and a decrease in vagal activity in the basal state where reduced sympathetic responsiveness has been observed during exercise Therefore these multiple exercise risk markers could provide valuable clinical information regarding cardiometabolic health Nonetheless HR behavior during CPET has not been described in obese adolescents The goal of this study is to examine the HR behavior of obese adolescents during CPET to clarify whether this population suffer from CI
During CPET mechanical constraints in ventilation an elevated risk for hypoxia and chronotropic incompetence CI defined as the inability of the heart to increase its rate with increased activity or compromised cardiac function eg lowered heart rate HR recovery chronotropic index and stroke volume are often observed in obese adults Moreover several studies regarding exercise capacity and cardiopulmonary responses to maximal endurance exercise testing have been performed in obese adolescents Despite these previous investigations in obese adolescents it remains controversial whether cardiopulmonary disturbances can be observed consistently during CPET However a number of studies have reported a suboptimal response to exercise in particular a reduced peak heart rate HRpeak and peak cycling power output Wpeak Adult obesity modifies cardiac behavior including resting HR and CI which has a marked effect on exercise capacity Therefore chronotropic variables are the most important factors that affect exercise performance It has been shown that both peak and resting HR account for over forty percent of variability of exercise capacity Interestingly resting HR and HR response to exercise including a blunted HR increase low chronotropic index and HR recovery are important predictors of all-cause mortality and cardiovascular death at least in adults These changes in HR during and recovery from CPET are mediated by the balance between sympathetic and vagal activity of the autonomic nervous system Adverse cardiovascular outcomes associated with the metabolic syndrome may be mediated by autonomic dysfunction whereby obesity is characterized by sympathetic predominance and a decrease in vagal activity in the basal state where reduced sympathetic responsiveness has been observed during exercise Therefore these multiple exercise risk markers could provide valuable clinical information regarding cardiometabolic health Nonetheless HR behavior during CPET has not been described in obese adolescents The goal of this study is to examine the HR behavior of obese adolescents during CPET to clarify whether this population suffer from CI
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None