Viewing Study NCT00376558



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Last Modification Date: 2024-10-26 @ 9:27 AM
Study NCT ID: NCT00376558
Status: COMPLETED
Last Update Posted: 2016-07-01
First Post: 2006-09-14

Brief Title: Imaging the Neurobiology of a Behavioral Treatment for Cocaine Dependence
Sponsor: New York State Psychiatric Institute
Organization: New York State Psychiatric Institute

Study Overview

Official Title: Imaging the Neurobiology of a Behavioral Treatment for Cocaine Dependence
Status: COMPLETED
Status Verified Date: 2016-05
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: PET-CRA
Brief Summary: The purpose of this study is to determine whether patients with the greatest loss of dopamine transmission due to cocaine dependence at pre-treatment PET and MRI scans will be those who fail to respond to substance abuse treatment This study will also determine whether patients who do respond to treatment will experience a recovery of dopamine function This study includes free brain imaging and behavioral intervention Compensation provided for the brain scans
Detailed Description: Previous studies have shown that cocaine dependence is associated with a decrease in dopamine release in response to a psychostimulant challenge We have recently completed a study demonstrating that this loss of pre-synaptic dopamine function is associated with the choice to self-administer cocaine in the presence of an alternative reinforcer This finding consistent with animal models of reinforcement and which show that dopamine transmission serves to modulate reward based behavior and in this case allows for a more adaptive response to be made in the presence of a competing reinforcer

The previous study was performed in non-treatment seeking cocaine dependent subjects using an inpatient laboratory model to measure the choice for cocaine Thus the goal of the present proposal is to investigate this association in a more realistic setting where cocaine dependent out patients face the choice between using cocaine and the alternative reinforcers presented to them in a therapeutic setting The Community Reinforcement Approach with voucher incentives is a treatment for cocaine dependence that has been shown success in a number of controlled studies Since the basis of this therapy is to reduce the reinforcing value of cocaine by increasing the density of alternative healthy reinforcers we have chosen to correlate outcome from this treatment with measures of presynaptic dopamine function We propose to scan cocaine dependent patients with 11Craclopride and oral methylphenidate in order to measure dopamine release Patients will be scanned before treatment and at 12 weeks into therapy We predict that the patients with the greatest loss of dopamine transmission at the pre-treatment scan will be those who fail to respond to treatment Furthermore we hypothesize that the patients who do respond to treatment will experience a recovery of dopamine function measured at the post-treatment scan

In addition subjects enrolled in this study will undergo functional Magnetic Resonance Imaging fMRI and spectroscopy studies in order to asses differences in neuronal integrity learning and impulse control

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: None
Is a FDA Regulated Device?: None
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None
Secondary IDs
Secondary ID Type Domain Link
R01DA020855-02 NIH None httpsreporternihgovquickSearchR01DA020855-02