Ignite Creation Date:
2024-05-05 @ 11:19 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00006173
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2000-08-11
Brief Title:
Magnetic Resonance Imaging for Evaluating Kidney Function
Sponsor:
National Institutes of Health Clinical Center CC
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Assessment of Renal Artery Stenosis and Renovascular Hypertension by Contrast Enhanced Magnetic Resonance Imaging A Pilot Study
Status:
COMPLETED
Status Verified Date:
2004-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Renovascular hypertension RVH is a potentially curable disease affecting 05-5 percent of patients with hypertension The current diagnostic work-up of RVH involves a complex algorithm which includes doppler ultrasound captopril renography and conventional angiography Because of the expense risk and inconvenience of this workup patients may not be correctly diagnosed
Advances in MR technology present the opportunity to develop a single comprehensive test This would combine an MR angiogram that provides anatomic information about the renal arteries and an MR renogram that provides information about the functional impact of a stenosis as a cause of hypertension Our main purpose is to test MR renography with and without an oral angiotensin converting enzyme inhibitor ACEI combined with MR angiography against the reference standard of captopril radionuclide renography Secondary goals of this study are to test whether hypoxia within ischemic kidneys affected by RVH is detectable by T2 weighted Blood oxygen level dependent or BOLD MRI This is considered of value since such a test of oxygenation would further shorten and simplify the diagnostic MR test Information gained from this study could lead to important changes in the diagnostic and pathophysiologic understanding of RVH
Advances in MR technology present the opportunity to develop a single comprehensive test This would combine an MR angiogram that provides anatomic information about the renal arteries and an MR renogram that provides information about the functional impact of a stenosis as a cause of hypertension Our main purpose is to test MR renography with and without an oral angiotensin converting enzyme inhibitor ACEI combined with MR angiography against the reference standard of captopril radionuclide renography Secondary goals of this study are to test whether hypoxia within ischemic kidneys affected by RVH is detectable by T2 weighted Blood oxygen level dependent or BOLD MRI This is considered of value since such a test of oxygenation would further shorten and simplify the diagnostic MR test Information gained from this study could lead to important changes in the diagnostic and pathophysiologic understanding of RVH
Detailed Description:
Renovascular hypertension RVH is a potentially curable disease affecting 05-5 of patients with hypertension The current diagnostic work-up of RVH involves a complex algorithm which includes doppler ultrasound captopril renography and conventional angiography Because of the expense risk and inconvenience of this workup patients may not be correctly diagnosed
Advances in MR technology present the opportunity to develop a single comprehensive test This would combine an MR angiogram that provides anatomic information about the renal arteries and an MR renogram that provides information about the functional impact of a stenosis as a cause of hypertension Our main purpose is to test MR renography with and without an oral angiotensin converting enzyme inhibitor ACEI combined with MR angiography against the reference standard of captopril radionuclide renography Secondary goals of this study are to test whether hypoxia within ischemic kidneys affected by RVH is detectable by T2 weighted Blood oxygen level dependent or BOLD MRI This is considered of value since such a test of oxygenation would further shorten and simplify the diagnostic MR test Information gained from this study could lead to important changes in the diagnosis and pathophysiologic understanding of RVH
Advances in MR technology present the opportunity to develop a single comprehensive test This would combine an MR angiogram that provides anatomic information about the renal arteries and an MR renogram that provides information about the functional impact of a stenosis as a cause of hypertension Our main purpose is to test MR renography with and without an oral angiotensin converting enzyme inhibitor ACEI combined with MR angiography against the reference standard of captopril radionuclide renography Secondary goals of this study are to test whether hypoxia within ischemic kidneys affected by RVH is detectable by T2 weighted Blood oxygen level dependent or BOLD MRI This is considered of value since such a test of oxygenation would further shorten and simplify the diagnostic MR test Information gained from this study could lead to important changes in the diagnosis and pathophysiologic understanding of RVH
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 00-CC-0195 | None | None | None |