Ignite Creation Date:
2024-05-05 @ 5:01 PM
Last Modification Date:
2024-10-26 @ 9:27 AM
Study NCT ID:
NCT00369876
Status:
UNKNOWN
Last Update Posted:
2007-01-24
First Post:
2006-08-29
Brief Title:
Anorexia in Children With Burn Injury and the Reactions of the Immune and Endocrine Systems
Sponsor:
Sheba Medical Center
Organization:
Sheba Medical Center
Study Overview
Official Title:
The Association Between Anorexia and the Level of Hormones Cytokines and Neuroendocrine Peptides in Children After Burn Injury
Status:
UNKNOWN
Status Verified Date:
2007-01
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Anorexia in children with burn injury is a common phenomenon The study is searching for the origin of the anorexia in those children The study correlates between the level peptides of the immune and the endocrine systems and the length of the anorexia
Detailed Description:
Burn injury lead to hypermetabolic set to heal the damaged tissueBurn healing uses high energy consumption and as consequence is highly There is a huge activation of the endocrine system and immune system resulting a proinflamtory status
The nutrition component has an important role in the burn healing process by reducing the healing time and also in the quality of the scar tissue Its been observed that many burn injury patients are suffering from anorexia Since we know pro-inflammatory status modulate satiety rises the question is there a correlation between the level peptides of the immune and the endocrine systems to anorexia in children with burn injury
Catecholamines serum concentrations rise following a burn injury These hormones have an important role in determining the basal metabolic rate BMR During the healing process the levels of growth hormone GH and Insulin like growth factor I IGF-1 are reduced Previous studies show a correlation between these lower levels and Interleukins and cytokines such as Tumor Necrosis Factor TNF Interleukin-6 IL-6 Additional hormones which are relevant are cortisol and insulin Cortisol levels are very high after severe burn injuries for a long period insulin sensitivity state also has an important role in the healing process
TNFa and IL-6 which are inflammatory factors found to have significantly elevated serum concentrations during the healing process They are also known to be reducers to GH sensitivity and causes anorexia
This study will show the connection between the immune and the endocrine systems to the burn healing process and anorexia by examining the level of hormones interleukins and neuropeptide during the burn healing our goal is to try and improve the treatment in children with burn injury by nutritional or drug intervention
The nutrition component has an important role in the burn healing process by reducing the healing time and also in the quality of the scar tissue Its been observed that many burn injury patients are suffering from anorexia Since we know pro-inflammatory status modulate satiety rises the question is there a correlation between the level peptides of the immune and the endocrine systems to anorexia in children with burn injury
Catecholamines serum concentrations rise following a burn injury These hormones have an important role in determining the basal metabolic rate BMR During the healing process the levels of growth hormone GH and Insulin like growth factor I IGF-1 are reduced Previous studies show a correlation between these lower levels and Interleukins and cytokines such as Tumor Necrosis Factor TNF Interleukin-6 IL-6 Additional hormones which are relevant are cortisol and insulin Cortisol levels are very high after severe burn injuries for a long period insulin sensitivity state also has an important role in the healing process
TNFa and IL-6 which are inflammatory factors found to have significantly elevated serum concentrations during the healing process They are also known to be reducers to GH sensitivity and causes anorexia
This study will show the connection between the immune and the endocrine systems to the burn healing process and anorexia by examining the level of hormones interleukins and neuropeptide during the burn healing our goal is to try and improve the treatment in children with burn injury by nutritional or drug intervention
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None