Ignite Creation Date:
2024-05-06 @ 1:48 PM
Last Modification Date:
2024-10-26 @ 1:20 PM
Study NCT ID:
NCT04123756
Status:
TERMINATED
Last Update Posted:
2024-02-22
First Post:
2019-10-10
Brief Title:
Predicting Outcome Following Standardized Exercise Therapy in Knee Osteoarthritis Patients
Sponsor:
Aalborg University
Organization:
Aalborg University
Study Overview
Official Title:
Smerteprofiler Som Redskab Til at prædiktere Effekten af 6-8 Ugers GLAD-forløb Hos Patienter Med Smertefuld Slidgigt i knæene
Status:
TERMINATED
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Recruitment issues due to the corona virus and lack of funding to continue
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Pain sensitization has been associated with pain severity in people with knee osteoarthritis KOA and a neuropathic pain component has been identified in up to 30 of KOA patients Mechanistic pain profiling aims to identify the underlying mechanisms in the peripheral and central nervous systems which are associated to the clinical pain
In addition the mechanisms underlying the pain relieving effect of standardized exercise therapy are largely unknown but it is hypothesized that they are linked to the patients ability to activate the descending pain inhibitory pathways conditioned pain modulation CPM in the central nervous system Mechanistic pain profiling including CPM have been used prognostic to identify responders to treatment but these measures as a prognostic tool for standardized exercise therapy has not been investigated
The primary aim of this study is to investigate if mechanistic pain profiling alone or in combination with clinical pain measures before standardized exercise therapy can predict the patients pain reduction following the exercise therapy program
In addition the mechanisms underlying the pain relieving effect of standardized exercise therapy are largely unknown but it is hypothesized that they are linked to the patients ability to activate the descending pain inhibitory pathways conditioned pain modulation CPM in the central nervous system Mechanistic pain profiling including CPM have been used prognostic to identify responders to treatment but these measures as a prognostic tool for standardized exercise therapy has not been investigated
The primary aim of this study is to investigate if mechanistic pain profiling alone or in combination with clinical pain measures before standardized exercise therapy can predict the patients pain reduction following the exercise therapy program
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None