Ignite Creation Date:
2024-05-05 @ 5:00 PM
Last Modification Date:
2024-10-26 @ 9:26 AM
Study NCT ID:
NCT00363987
Status:
COMPLETED
Last Update Posted:
2010-09-02
First Post:
2006-08-13
Brief Title:
Controlled Study to Evaluate Efficacy and Safety of α-KA Tab With Low Protein Diet LPD in Delaying the Progress of Type 2 Diabetic Nephropathy DN
Sponsor:
Fresenius Kabi
Organization:
Fresenius Kabi
Study Overview
Official Title:
A Multicenter Randomized Open-label Parallel-group Diabetic Diet-controlled Study to Evaluate the Efficacy and Safety of Compound α-Keto Acid Tablet in Combination With LPD in Delaying the Progress of Type 2 Diabetic Nephropathy
Status:
COMPLETED
Status Verified Date:
2010-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Current expert opinion based consensus guidelines recommend usage of α-Keto analogues of essential amino acids in the diet of diabetic nephropathy patients along with restricted protein diets This study is designed to explore whether alpha-Keto Acid supplementation with low protein diet will retard progression of type 2 diabetic nephropathy and also to assess effects of such supplemented diets on nutritional and other parameters in this patient group
Detailed Description:
Diabetic nephropathy is the most common cause for end-stage renal disease ESRD in Europe and America which is directly related to rising incidence of type 2 diabetes In addition life lengthening of diabetic patients and ESRD patients receiving regular therapy are also important cause According to data in the year of 1977 40 of newly diagnosed ESRD patients in USA were caused by diabetes Duo to enormous number and incessant increasing incidence of type 2 diabetic patients type 2 diabetic nephropathy patients have already accounted for considerable proportion in the diabetic nephropathy patients who need dialysis Recently in China the incidence of type 2 diabetes shows a tendency to escalate It is expected that the number of diabetic patients will be up to 32 million in 2010
α-Keto Acid is a product of amino acid deamination Because it is nonnitrogenous and can accept amino to turn into the corresponding amino acid through transaminase in the body of patient with chronic renal failure α-Keto Acid can reduce nitrogen supply decrease urea production stimulate protein synthesis suppress protein decomposition while offering adequate essential amino acids for body Furthermore α-Keto Acid and branched chain amino acids do not stimulate glucagon secretion and glucagon-induced cAMP secretion in liver has no stimulating effect on hyperfiltration thus contribute to delaying the progress of nephropathy
It is extensively accepted that limited intake of diet protein to reduce kidney hyperfiltration and renal glomerulus internal pressure is effective in delaying the progress of nephropathy But at present debate exists in clinical research papers such as MDRDS to the role of low protein diet in delaying the progress of nephropathy Adding compound α-Keto Acid tablet to low protein diet for patients can prevent essential amino acid deficiency and ameliorate severity of metabolism disorder thus prevent malnutrition Compared with standard diabetic diet the aim of this study is to evaluate the efficacy and safety of compound α-Keto Acid tablet in combination with low protein diet in delaying the progress of nephropathy
This is a multicentre randomized open-label parallel group diabetic diet controlled study 240 patients who meet InclusionExclusion criteria will be randomized into test groups or control groups at the ratio of 11 Test group will use low protein diet in combination with compound α-Keto Acid tablet while control group will use routine diabetic diet efficacy and safety of test group will be compared with those of control group after 1 year treatment The study will be performed at 12 centres to ensure that at least 200 evaluable subjects are obtained
STUDY OBJECTIVES
To compare the efficacy ameliorating proteinuria and kidney injury of compound α-Keto Acid tablet in combination with low protein diet with that of standard diabetic diet in delaying the progress of type 2 diabetic nephropathy
To compare the safety of compound α-Keto Acid tablet in combination with low protein diet with that of standard diabetic diet in delaying the progress of type 2 diabetic nephropathy
Primary Endpoint one year of treatment with Low Protein Diet plus α-Keto Acid or Diabetic Diet Secondary Endpoint Death Dialysis or renal transplantation
α-Keto Acid is a product of amino acid deamination Because it is nonnitrogenous and can accept amino to turn into the corresponding amino acid through transaminase in the body of patient with chronic renal failure α-Keto Acid can reduce nitrogen supply decrease urea production stimulate protein synthesis suppress protein decomposition while offering adequate essential amino acids for body Furthermore α-Keto Acid and branched chain amino acids do not stimulate glucagon secretion and glucagon-induced cAMP secretion in liver has no stimulating effect on hyperfiltration thus contribute to delaying the progress of nephropathy
It is extensively accepted that limited intake of diet protein to reduce kidney hyperfiltration and renal glomerulus internal pressure is effective in delaying the progress of nephropathy But at present debate exists in clinical research papers such as MDRDS to the role of low protein diet in delaying the progress of nephropathy Adding compound α-Keto Acid tablet to low protein diet for patients can prevent essential amino acid deficiency and ameliorate severity of metabolism disorder thus prevent malnutrition Compared with standard diabetic diet the aim of this study is to evaluate the efficacy and safety of compound α-Keto Acid tablet in combination with low protein diet in delaying the progress of nephropathy
This is a multicentre randomized open-label parallel group diabetic diet controlled study 240 patients who meet InclusionExclusion criteria will be randomized into test groups or control groups at the ratio of 11 Test group will use low protein diet in combination with compound α-Keto Acid tablet while control group will use routine diabetic diet efficacy and safety of test group will be compared with those of control group after 1 year treatment The study will be performed at 12 centres to ensure that at least 200 evaluable subjects are obtained
STUDY OBJECTIVES
To compare the efficacy ameliorating proteinuria and kidney injury of compound α-Keto Acid tablet in combination with low protein diet with that of standard diabetic diet in delaying the progress of type 2 diabetic nephropathy
To compare the safety of compound α-Keto Acid tablet in combination with low protein diet with that of standard diabetic diet in delaying the progress of type 2 diabetic nephropathy
Primary Endpoint one year of treatment with Low Protein Diet plus α-Keto Acid or Diabetic Diet Secondary Endpoint Death Dialysis or renal transplantation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None