Ignite Creation Date:
2024-05-05 @ 5:00 PM
Last Modification Date:
2024-10-26 @ 9:26 AM
Study NCT ID:
NCT00360919
Status:
COMPLETED
Last Update Posted:
2012-08-07
First Post:
2006-08-03
Brief Title:
Assessing the Presence of Casomorphins in Human Plasma After Dairy Ingestion
Sponsor:
Physicians Committee for Responsible Medicine
Organization:
Physicians Committee for Responsible Medicine
Study Overview
Official Title:
Assessing the Presence of Casomorphins in Human Plasma After Dairy Ingestion
Status:
COMPLETED
Status Verified Date:
2012-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This purpose of this study is to perform a pilot investigation to determine if opioid peptides such as casomorphin can be detected in human plasma after cheese ingestion
Detailed Description:
Cheese is one of the most commonly craved foods suggesting the possibility of opiate activity as has been demonstrated with other craved foods particularly chocolate Like other dairy products cheese contains casein which is the major protein in cows milk This is unlike human milk in which the primary protein is whey Casein includes αs1- αs2- β- and κ-casein with αs1 and β forms predominating Human and bovine casein molecules are cleaved during digestion to release opioid peptides that are believed to have biological properties relevant to infant physiology and behavior Specifically β-casein is cleaved to form β-casomorphins Like other opiate agonists β-casomorphins prolong gastrointestinal transit time and have an antidiarrheal effect
Casomorphin receptor binding has been demonstrated in opiate receptor assays and bioassays Duodenal aspirates from human volunteers given cows milk have demonstrated the presence of several casomorphins particularly β-casomorphin-7 Few studies have assessed the presence or action of casomorphins in humans The ability of casein-derived opioid peptides to pass into the bloodstream is not well characterized and is the subject of the present study
Casomorphin receptor binding has been demonstrated in opiate receptor assays and bioassays Duodenal aspirates from human volunteers given cows milk have demonstrated the presence of several casomorphins particularly β-casomorphin-7 Few studies have assessed the presence or action of casomorphins in humans The ability of casein-derived opioid peptides to pass into the bloodstream is not well characterized and is the subject of the present study
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None